Evidence map›Paper›PMID 23931139›Full record

ArticleStructure (London, England : 1993)2013

TGF-β antagonists: same knot, but different hold.

Andrew P Hinck, Tao Huang

Open access · bronzeAbstract readComment
In one paragraph

Article in Structure (London, England : 1993), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Follistatin Effects in Migration, Vascularization, and OsteogenesisFrontiers in bioengineering and biotechnology · 2019
    Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Andrew P HinckDepartment of Biochemistry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229-3900, USA. hinck@uthscsa.edu
Tao Huang
National Cancer Institute · USThe University of Texas Health Science Center at San Antonio · US

Funding

TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Lei Zheng · 1991 to 2026
$59.1M
LIGAND/RECEPTOR INTERACTIONS IN THE TGF BETA SUPERFAMILYR01GM058670 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI HINCK, ANDREW P · 1999 to 2017
$3.6M
Inhibition of the tumor-promoting effects of TGF-beta in advanced prostate cancerR01CA172886 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI HINCK, ANDREW P, SUN, LUZHE · 2013 to 2016
$1.2M
NCI NIH HHS P30 CA054174NCI NIH HHS R01 CA172886NIGMS NIH HHS R01 GM058670
6 · The paper itself

Abstract

In this issue of Structure, Nolan and colleagues present the structure of BMP antagonist, PRDC, which adopts a head-to-tail dimer with distinct structure and inhibitory mechanism compared to other dimeric antagonists of the TGF-β superfamily, such as noggin.

Indexed as

AnimalsBone Morphogenetic Protein 2CytokinesProteinsBmp2 protein, mouseBone Morphogenetic Protein 2CytokinesGrem2 protein, mouseProteins

Identifiers

PMID23931139
PMCPMC3809007
OpenAlexW1981977933

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.