ArticleThe journal of physical chemistry. B2013
Two-dimensional heterospectral correlation analysis of the redox-induced conformational transition in cytochrome c using surface-enhanced Raman and infrared absorption spectroscopies on a two-layer gold surface.
Article in The journal of physical chemistry. B, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 46 citations in OpenAlex.
- Recent Advances in Analytical Platform for Single-Cell Microbial Electrochemistry.Chemical & biomedical imaging · 2026Review
- Surface-Bulk Correlation Spectroscopy for the Characterization of Ternary Adsorption.Applied spectroscopy · 2026Article
- Optimization and Enhancement of the Peroxidase-like Activity of Hemin in Aqueous Solutions of Sodium Dodecylsulfate.ACS omega · 2023Article
- Reaction intermediate rotation during the decarboxylation of coproheme to heme b in C. diphtheriae.Biophysical journal · 2021Article
- Article
- Actinobacterial Coproheme Decarboxylases Use Histidine as a Distal Base to Promote Compound I Formation.ACS catalysis · 2020Article
- Interaction between Cellobiose Dehydrogenase and Lytic Polysaccharide Monooxygenase.Biochemistry · 2019Article
- Article
- Investigation of ion binding in chlorite dismutases by means of molecular dynamics simulations.Biochemistry · 2014Article
- Dihedral-based segment identification and classification of biopolymers I: proteins.Journal of chemical information and modeling · 2014Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
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Abstract
The heme protein cytochrome c adsorbed to a two-layer gold surface modified with a self-assembled monolayer of 2-mercaptoethanol was analyzed using a two-dimensional (2D) heterospectral correlation analysis that combined surface-enhanced infrared absorption spectroscopy (SEIRAS) and surface-enhanced Raman spectroscopy (SERS). Stepwise increasing electric potentials were applied to alter the redox state of the protein and to induce conformational changes within the protein backbone. We demonstrate herein that 2D heterospectral correlation analysis is a particularly suitable and useful technique for the study of heme-containing proteins as the two spectroscopies address different portions of the protein. Thus, by correlating SERS and SEIRAS data in a 2D plot, we can obtain a deeper understanding of the conformational changes occurring at the redox center and in the supporting protein backbone during the electron transfer process. The correlation analyses are complemented by molecular dynamics calculations to explore the intramolecular interactions.
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