ArticleHippokratia2012
Gender and morphogenetic variability of patients with spina bifida occulta and spina bifida aperta: prospective population-genetic study.
Article in Hippokratia, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03481764 (Anthropogenetic Variability in the Group of Individuals With Febrile Seizures - Population Genetic Study), which is not on this map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Anthropogenetic Variability in the Group of Individuals With Febrile Seizures - Population Genetic Study
Who cites it
3 citing papers in PubMed, 8 citations in OpenAlex.
- Genetic and Environmental Dispositions for Cardiovascular Variability: A Pilot Study.Journal of clinical medicine · 2018Article
- The Gender Impact on Morphogenetic Variability in Coronary Artery Disease: A Preliminary Study.Journal of clinical medicine · 2018Article
- Anthropogenetic Variability in the Group of Individuals with Febrile Seizures: Population-Genetic Study.BioMed research international · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAim of our study was to evaluate degree of genetic homozygosity in male and female gender of spina bifida (SB) occulta and SB aperta patients. PATIENTS AND
methodsWe evaluated 95 patients with SB occulta and 51 with SB aperta. Degree of genetic homozygosity was evaluated by direct observation of 15 homozygously recessive characteristics (HRC) by HRC-test separately for SB occulta and SB aperta participants. Additionally 370 individuals without SB from Serbia were randomly selected and evaluated as control group. Male and female gender was separately evaluated for assessing degree of genetic homozygosity.
resultsThere was no significant difference in mean values of HRC between male and female gender in control group (male gender -3.9±1.2, female gender -4.0±1.4, z=0.39; p>0.05), SB occulta (male gender -4.1±1.5, female gender -4.7±1.4, z=1.87, p>0.05) and SB aperta patients (male gender -4.3±1.6, female gender -4.5±1.4, z=0.66, p>0.05), while there was significantly increased recessive homozygosity in female SB occulta group versus control female group (Females: SB occulta -4.7±1.4, Control group -4.0±1.4, z=3.16, p<0.01) and female SB aperta group versus control female group (Females: SB aperta -4.5±1.4, Control group -4.0±1.4, z=2.05, p<0.05).
conclusionThere is increased recessive homozygosity in tested female SB occulta and female SB aperta individuals versus SB male participants and significantly increased recessive homozygosity in female groups of SB patients versus control female group. These findings could lead to the possible assumption that different genes in different degree might be expressed in SB occulta and SB aperta patients.
Indexed as
Identifiers
23930055PMC3738390W1798449867What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.