ArticleInternational immunology2013
TGF-β type II receptor expression in thymic epithelial cells inhibits the development of Hassall's corpuscles in mice.
Article in International immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- BRCA1 deficiency leads to aberrant epithelial differentiation in the thymus.ImmunoHorizons · 2025Article
- An iPSC-based in vitro model recapitulates human thymic epithelial development and multi-lineage specification.Nature communications · 2025Article
- Advanced three-dimensional X-ray imaging unravels structural development of the human thymus compartments.Communications medicine · 2024Article
- Next-generation effects of fetal and lactational exposure to the neonicotinoid pesticide clothianidin on the immune system and gut microbiota.The Journal of veterinary medical science · 2023Article
- Article
- Thymus Gland: A Double Edge Sword for Coronaviruses.Vaccines · 2021Review
- Thymus and autoimmunity.Seminars in immunopathology · 2021Review
- The thymus medulla and its control of αβT cell development.Seminars in immunopathology · 2021Review
- CD147 deficiency in T cells prevents thymic involution by inhibiting the EMT process in TECs in the presence of TGFβ.Cellular & molecular immunology · 2021Article
- Review
- Thymic epithelial cell heterogeneity: TEC by TEC.Nature reviews. Immunology · 2020Review
- Hassall's corpuscles with cellular-senescence features maintain IFNα production through neutrophils and pDC activation in the thymus.International immunology · 2019Article
- Article
- Niches for the Long-Term Maintenance of Tissue-Resident Memory T Cells.Frontiers in immunology · 2018Review
- Developing stratified epithelia: lessons from the epidermis and thymus.Wiley interdisciplinary reviews. Developmental biologyReview
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Authors and funding
8 authors at 4 institutions in 5 countries.
Funding
Abstract
Hassall's corpuscles are concentric clusters of keratinized epithelial cells located within the thymic medulla of humans and guinea pigs but are scant in mouse and rat. They are considered to be the terminally differentiated stages of medullary thymic epithelial cells (mTECs) but the mechanisms of their origin are unclear. We have previously deleted the TGF-β type II receptor (TGFβRII) specifically in mouse TECs and reported that these mice have mitigated thymic involution and exhibit earlier reconstitution post-irradiation. In this study, we analyzed the differentiation of mTECs in the TGFβRII-knockout mice. Interestingly, the TGFβRII-knockout mice display enhanced development of Hassall's corpuscles. The expression of Aire, stromal-cell-derived factor 1 and thymic stromal lymphopoietin in the thymi of the TGFβRII-knockout mice was similar to that previously reported for the human thymus. In addition, the putative epithelial progenitor markers MTS20 and MTS24 labeled Hassall's corpuscles in normal mice, but the extent and intensity of this staining were greatly enhanced in Hassall's corpuscles of the TGFβRII-knockout mice. The phosphorylated forms of ERK and JNK were also found in Hassall's corpuscles of the TGFβRII-knockout mice. Taken together, we suggest that TGFβRII-mediated signaling in TECs inhibits their development into Hassall's corpuscles in mice.
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