ArticleStroke2013
Optimizing prediction scores for poor outcome after intra-arterial therapy in anterior circulation acute ischemic stroke.
Article in Stroke, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 56 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 2 syntheses or guidelines pooled it, 108 citations in OpenAlex.
- Associations between basic physiological observations recorded pre-thrombectomy and functional outcome: a systematic review and meta-analysis.Frontiers in stroke · 2023Pooled it
- Outcome Prediction Models for Endovascular Treatment of Ischemic Stroke: Systematic Review and External Validation.Stroke · 2022Pooled it
- The THRIVE score strongly predicts outcomes in patients treated with the Solitaire device in the SWIFT and STAR trials.International journal of stroke : official journal of the International Stroke Society · 2014Trial
- Trial
- THRIVE score predicts outcomes with a third-generation endovascular stroke treatment device in the TREVO-2 trial.Stroke · 2013Trial
- Predictors of devastating functional outcome despite successful basilar thrombectomy.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2026Article
- Development and validation of an explainable machine learning prediction model for futile recanalization after mechanical thrombectomy in acute large vessel occlusion stroke.Journal of neurointerventional surgery · 2026Article
- Predicting severe disability or death in endovascular thrombectomy with large computed tomography perfusion core infarction and limited penumbra.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2026Article
- Do scoring systems help us to estimate prognosis after mechanical thrombectomy? Data from the German Stroke Registry.Journal of neurointerventional surgery · 2026Article
- Risk score for futile recanalization: integrating cerebral circulation time and collateral cascade.Frontiers in aging neuroscience · 2026Article
- Interpretable machine learning-based prediction of 90-day mortality after endovascular treatment in acute large vessel occlusion stroke.Frontiers in neurology · 2026Article
- SMART-M24: A Prognostic Nomogram for Long-Term Mortality in Acute Ischemic Stroke Beyond 24 H from Symptom Onset.Translational stroke research · 2025Article
- Behavioral Clusters and Lesion Distributions in Ischemic Stroke, Based on NIHSS Similarity Network.Journal of healthcare informatics research · 2025Article
- Validation of the Charlotte Large Artery Occlusion Endovascular Therapy Outcome Score in a Modern Cohort of Thrombectomy Patients.Neurology international · 2025Article
- Identification and Patient Benefit Evaluation of Machine Learning Models for Predicting 90-Day Mortality After Endovascular Thrombectomy Based on Routinely Ready Clinical Information.Bioengineering (Basel, Switzerland) · 2025Article
- Long-term functional outcomes for elderly patients treated with endovascular thrombectomy.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Novel Risk Score to Predict Poor Outcome After Endovascular Treatment in Anterior Circulation Occlusive Acute Ischemic Stroke.Journal of the American Heart Association · 2025Article
- Validation of the Charlotte large artery occlusion endovascular therapy outcome score using Viz.ai-derived cerebral blood volume index.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Machine learning models integrating intracranial artery calcification to predict outcomes of mechanical thrombectomy.Frontiers in neurology · 2025Article
- Nomogram-Based Prediction of 3-Month Unfavorable Outcome and Early Neurological Deterioration After Endovascular Thrombectomy in Acute Ischemic Stroke.Therapeutics and clinical risk management · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
26 authors at 4 institutions in 2 countries.
Funding
Abstract
background and purposeIntra-arterial therapy (IAT) promotes recanalization of large artery occlusions in acute ischemic stroke. Despite high recanalization rates, poor clinical outcomes are common. We attempted to optimize a score that combines clinical and imaging variables to more accurately predict poor outcome after IAT in anterior circulation occlusions.
methodsPatients with acute ischemic stroke undergoing IAT at University of Texas (UT) Houston for large artery occlusions (middle cerebral artery or internal carotid artery) were reviewed. Independent predictors of poor outcome (modified Rankin Scale, 4-6) were studied. External validation was performed on IAT-treated patients at Emory University.
resultsA total of 163 patients were identified at UT Houston. Independent predictors of poor outcome (P≤0.2) were identified as score variables using sensitivity analysis and logistic regression. Houston Intra-Arterial Therapy 2 (HIAT2) score ranges 0 to 10: age (≤59=0, 60-79=2, ≥80 years=4), glucose (<150=0, ≥150=1), National Institute Health Stroke Scale (≤10=0, 11-20=1, ≥21=2), the Alberta Stroke Program Early CT Score (8-10=0, ≤7=3). Patients with HIAT2≥5 were more likely to have poor outcomes at discharge (odds ratio, 6.43; 95% confidence interval, 2.75-15.02; P<0.001). After adjusting for reperfusion (Thrombolysis in Cerebral Infarction score≥2b) and time from symptom onset to recanalization, HIAT2≥5 remained an independent predictor of poor outcome (odds ratio, 5.88; 95% confidence interval, 1.96-17.64; P=0.02). Results from the cohort of Emory (198 patients) were consistent; patients with HIAT2 score≥5 had 6× greater odds of poor outcome at discharge and at 90 days. HIAT2 outperformed other previously published predictive scores.
conclusionsThe HIAT2 score, which combines clinical and imaging variables, performed better than all previous scores in predicting poor outcome after IAT for anterior circulation large artery occlusions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.