ArticleMagnetic resonance in medicine2014
Assessing intrarenal nonperfusion and vascular leakage in acute kidney injury with multinuclear (1) H/(19) F MRI and perfluorocarbon nanoparticles.
Article in Magnetic resonance in medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Research progress of nanoparticles in the diagnosis and treatment of renal ischemia-reperfusion injury.Journal of nanobiotechnology · 2026Review
- The Current Application Prospects of Nanomedicine in Renal Ischemia-Reperfusion Injury.International journal of nanomedicine · 2026Review
- NovelMedical physics · 2025Article
- Wideband receive-coil array design using high-impedance amplifiers for broadband decoupling.Magnetic resonance in medicine · 2023Article
- Rapamycin Perfluorocarbon Nanoparticle Mitigates Cisplatin-Induced Acute Kidney Injury.International journal of molecular sciences · 2023Article
- Review
- Evaluation of renal cold ischemia-reperfusion injury with intravoxel incoherent motion diffusion-weighted imaging and blood oxygenation level-dependent MRI in a rat model.Frontiers in physiology · 2023Article
- Clinical and experimental approaches for imaging of acute kidney injury.Clinical and experimental nephrology · 2021Review
- Dynamic Contrast Enhanced-MR CEST Urography: An Emerging Tool in the Diagnosis and Management of Upper Urinary Tract Obstruction.Tomography (Ann Arbor, Mich.) · 2021Review
- Phenotyping placental oxygenation in Lgals1 deficient mice usingScientific reports · 2021Article
- Functional Imaging Using Fluorine (Methods in molecular biology (Clifton, N.J.) · 2021Article
- Hardware Considerations for Preclinical Magnetic Resonance of the Kidney.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Fluorine (Methods in molecular biology (Clifton, N.J.) · 2021Article
- Data Preparation Protocol for Low Signal-to-Noise Ratio Fluorine-19 MRI.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Perfluorocarbons-BasedInternational journal of nanomedicine · 2020Review
- Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs by orders of magnitude.Nature communications · 2018Article
- Quantification of vascular damage in acute kidney injury with fluorine magnetic resonance imaging and spectroscopy.Magnetic resonance in medicine · 2018Article
- Mitochondria-targeted antioxidant MitoQ reduced renal damage caused by ischemia-reperfusion injury in rodent kidneys: Longitudinal observations of TMagnetic resonance in medicine · 2018Article
- Is Testosterone Detrimental to Renal Function?Kidney international reports · 2016Article
- A porphyrin-PEG polymer with rapid renal clearance.Biomaterials · 2016Article
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Authors and funding
10 authors.
Funding
Abstract
purposeWe sought to develop a unique sensor-reporter approach for functional kidney imaging that employs circulating perfluorocarbon nanoparticles and multinuclear (1) H/(19) F MRI.
methods(19) F spin density weighted and T1 weighted images were used to generate quantitative functional mappings of both healthy and ischemia-reperfusion (acute kidney injury) injured mouse kidneys. (1) H blood-oxygenation-level-dependent (BOLD) MRI was also employed as a supplementary approach to facilitate the comprehensive analysis of renal circulation and its pathological changes in acute kidney injury.
resultsHeterogeneous blood volume distributions and intrarenal oxygenation gradients were confirmed in healthy kidneys by (19) F MRI. In a mouse model of acute kidney injury, (19) F MRI, in conjunction with blood-oxygenation-level-dependent MRI, sensitively delineated renal vascular damage and recovery. In the cortico-medullary junction region, we observed 25% lower (19) F signal (P < 0.05) and 70% longer (1) H T2* (P < 0.01) in injured kidneys compared with contralateral kidneys at 24 h after initial ischemia-reperfusion injury. We also detected 71% higher (19) F signal (P < 0.01) and 40% lower (1) H T2* (P < 0.05) in the renal medulla region of injured kidneys compared with contralateral uninjured kidneys.
conclusionIntegrated (1) H/(19) F MRI using perfluorocarbon nanoparticles provides a multiparametric readout of regional perfusion defects in acutely injured kidneys.
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