Evidence map›Paper›PMID 23929660›Full record

Trial reportObesity (Silver Spring, Md.)2014

Modifying influence of dietary sugar in the relationship between cortisol and visceral adipose tissue in minority youth.

Lauren E Gyllenhammer, Marc J Weigensberg, Donna Spruijt-Metz, Hooman Allayee, Michael I Goran, Jaimie N Davis

Open access · bronzeAbstract readClinical TrialComparative StudyObservational Study
In one paragraph

Trial report in Obesity (Silver Spring, Md.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 16 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Lauren E GyllenhammerDepartment of Preventive Medicine, Diabetes and Obesity Research Institute University of Southern California, Los Angeles, California, USA.
Marc J Weigensberg
Donna Spruijt-Metz
Hooman Allayee
Michael I Goran
Jaimie N Davis
University of Southern California · USThe University of Texas at Austin · US

Funding

ZOPOLRESTAT IN NORMOTENSIVE, TYPE 1 DIA WITH INCIPIENT NEPHROPATHYM01RR000043 · NCRR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ZAIA, JOHN A · 1985 to 2010
$76.4M
USC Center for Transdisciplinary Research on Energetics*U54CA116848 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GORAN, MICHAEL ISAAC · 2005 to 2010
$12.1M
Using resistance training to reduce metabolic and cardiovascular disease risk inP60MD002254 · NIMHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GORAN, MICHAEL ISAAC · 2007 to 2011
$8.1M
INTRA-ABDOMINAL FAT AND RISK OF DISEASE IN ADOLESCENTSR01HD033064 · NICHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GORAN, MICHAEL ISAAC · 1996 to 2008
$3.7M
Circuit Training and Motivational Interviewing to Reduce Type 2 Diabetes in YouthK01DK078858 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DAVIS, JAIMIE NICOLE · 2007 to 2010
$503k
NCI NIH HHS U54 CA116848NCI NIH HHS U54CA116848NCRR NIH HHS M01 RR000043NICHD NIH HHS R01HD0033064NICHD NIH HHS R01 HD033064NIDDK NIH HHS 1K01DK078858NIDDK NIH HHS K01 DK078858NIMHD NIH HHS 1P60MD002254-03NIMHD NIH HHS P60 MD002254
6 · The paper itself

Abstract

objectiveCortisol has been associated with preferential visceral adipose tissue (VAT) deposition; however, findings in humans are mixed, which may be clarified when diet is considered. DESIGN AND

methodsParticipants included 165 African-American and Latino, overweight adolescents (BMI% 97.2±3.2%, ages 13-18, 67% Latino, 66% female). Body composition was determined by dual energy X-ray absorptiometry, abdominal fat depots [VAT, subcutaneous (SAT)] by multiple-slice MRI, time-controlled serum sample to measure cortisol, and 2-day multi-pass 24-hour dietary recall. Linear regression analysis examined the cross-sectional relationship between cortisol, and the interaction of diet and cortisol on adiposity measures. Sex, race, age, and total body fat were a priori covariates.

resultsThere was a significant interaction between cortisol and sugar (total and added) in the prediction of VAT (P(interaction)  ≤ 0.05). Amongst participants with high total or added-sugar intake, cortisol was significantly associated with VAT (ß = 0.031 P < 0.001; ß = 0.026 P < 0.001), with no relationship in low consumers of total or added-sugar.

conclusionDietary sugar may play an important role in modifying the relationship between cortisol and VAT, such that cortisol is significantly associated with elevated VAT under conditions of high sugar intake.

Indexed as

AdiposityAdolescent Nutritional Physiological PhenomenaAdolescentAdolescent BehaviorBlack or African AmericanBody Mass IndexCross-Sectional StudiesDietDietary SucroseFemaleHispanic or LatinoHumansHydrocortisoneIntra-Abdominal FatLos AngelesMaleDietary SucroseHydrocortisone

Identifiers

PMID23929660
PMCPMC3946447
OpenAlexW2102642279

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.