ReviewHippocampus2013
Modulation of multiple memory systems: from neurotransmitters to metabolic substrates.
Review in Hippocampus, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 47 citations in OpenAlex.
- Neurometabolic substrate utilization governs oxidative phosphorylation conductance in cortex and hippocampus.Journal of neurophysiology · 2026Article
- Enhancement of response learning in male rats with intrastriatal infusions of a BDNF -TrkB agonist, 7,8-dihydroxyflavone.Behavioural brain research · 2026Article
- Sexual and Metabolic Differences in Hippocampal Evolution: Alzheimer's Disease Implications.Life (Basel, Switzerland) · 2024Review
- Glucose may Contribute to Retrieval and Reconsolidation of Contextual Fear Memory Through Hippocampal Nr4a3 and Bdnf mRNA Expression and May Act Synergically with Adrenaline.Molecular neurobiology · 2024Article
- Hippocampus-sensitive and striatum-sensitive learning one month after morphine or cocaine exposure in male rats.Pharmacology, biochemistry, and behavior · 2022Article
- Lactate Is Answerable for Brain Function and Treating Brain Diseases: Energy Substrates and Signal Molecule.Frontiers in nutrition · 2022Review
- Time-dependent changes in hippocampal and striatal glycogen long after maze training in male rats.Neurobiology of learning and memory · 2021Article
- Extracellular levels of glucose in the hippocampus and striatum during maze training for food or water reward in male rats.Behavioural brain research · 2021Article
- Estradiol selectively regulates metabolic substrates across memory systems in models of menopause.Climacteric : the journal of the International Menopause Society · 2021Article
- Interindividual differences in memory system local field potential activity predict behavioral strategy on a dual-solution T-maze.Hippocampus · 2020Article
- Emotionality modulates the impact of chronic stress on memory and neurogenesis in birds.Scientific reports · 2020Article
- Aging is not equal across memory systems.Neurobiology of learning and memory · 2020Article
- Inactivation of the striatum in aged rats rescues their ability to learn a hippocampus-sensitive spatial navigation task.Neurobiology of learning and memory · 2020Article
- Testosterone replacement causes dose-dependent improvements in spatial memory among aged male rats.Psychoneuroendocrinology · 2020Article
- Place vs. Response Learning: History, Controversy, and Neurobiology.Frontiers in behavioral neuroscience · 2020Article
- GluT4: A central player in hippocampal memory and brain insulin resistance.Experimental neurology · 2020Review
- The amnestic agent anisomycin disrupts intrinsic membrane properties of hippocampal neurons via a loss of cellular energetics.Journal of neurophysiology · 2019Article
- Involvement of lactate transport in two object recognition tasks that require either the hippocampus or striatum.Behavioral neuroscience · 2019Article
- Using a memory systems lens to view the effects of estrogens on cognition: Implications for human health.Physiology & behavior · 2018Article
- Environmental Enrichment Reverses Tyrosine Kinase Inhibitor-Mediated Impairment Through BDNF-TrkB Pathway.Molecular neurobiology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
This article reviews evidence showing that neurochemical modulators can regulate the relative participation of the hippocampus and striatum in learning and memory tasks. For example, relative release of acetylcholine increases in the hippocampus and striatum reflects the relative engagement of these brain systems during learning of place and response tasks. Acetylcholine release is regulated in part by available brain glucose levels, which themselves are dynamically modified during learning. Recent findings suggest that glucose acts through astrocytes to deliver lactate to neurons. Brain glycogen is contained in astrocytes and provides a capacity to deliver energy substrates to neurons when needed, a need that can be generated by training on tasks that target hippocampal and striatal processing mechanisms. These results integrate an increase in blood glucose after epinephrine release from the adrenal medulla with provision of brain energy substrates, including lactate released from astrocytes. Together, the availability of peripheral and central energy substrates regulate the processing of learning and memory within and across multiple neural systems. Dysfunctions of the physiological steps that modulate memory--from hormones to neurotransmitters to metabolic substrates--may contribute importantly to some of the cognitive impairments seen during normal aging and during neurodegenerative diseases.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.