ArticleLasers in medical science2015
Effects of increased low-level diode laser irradiation time on extraction socket healing in rats.
Article in Lasers in medical science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- The effectiveness of photobiomodulation therapy on bone regeneration of oral and craniofacial defects. A systematic review of animal, and in-vitro studies.Lasers in medical science · 2025Pooled it
- Efficacy of photobiomodulation on accelerating bone healing after tooth extraction: a systematic review.Lasers in medical science · 2019Pooled it
- Comprehensive analysis of bone tissue in extraction sockets of third molars after leukocyte and platelet rich fibrin and photobiomodulation applications.Clinical oral investigations · 2024Trial
- The adjunctive use of antimicrobial photodynamic therapy, light-emitting-diode photobiomodulation and ozone therapy in regenerative treatment of stage III/IV grade C periodontitis: a randomized controlled clinical trial.Clinical oral investigations · 2024Trial
- Photobiomodulation as an adjunctive therapy for alveolar socket preservation: a preliminary study in humans.Lasers in medical science · 2020Trial
- Effects of low-level laser therapy on soft and hard tissue healing after endodontic surgery.Lasers in medical science · 2018Trial
- Cross-Linked Hyaluronic Acid and Laser Photobiomodulation in Guided Bone Regeneration (GBR): A Case Report Describing a New Combined Technique.Case reports in dentistry · 2026Article
- A radiographic and histological study to compare red (650 nm) versus near infrared (810 nm) diode lasers photobiomodulation for alveolar socket preservation.Scientific reports · 2024Article
- Bone Regeneration of Rat Critical-Sized Calvarial Defects by the Combination of Photobiomodulation and Adipose-Derived Mesenchymal Stem Cells.Journal of lasers in medical sciences · 2024Article
- Effects of NGF and Photobiomodulation Therapy on Crush Nerve Injury and Fracture Healing: A Stereological and Histopathological Study in an Animal Model.Craniomaxillofacial trauma & reconstruction · 2023Article
- The effect of bone remodeling with photobiomodulation in dentistry: a review study.Lasers in medical science · 2023Review
- Nd:YAG-photobiomodulation enhanced ADSCs multilineage differentiation and immunomodulation potentials.Lasers in medical science · 2023Article
- Photobiomodulation effect in tumoral necrosis factor-alpha(TNF-α) on the viability of random skin flap in rats.Lasers in medical science · 2022Article
- Near-infrared 940-nm diode laser photobiomodulation of inflamed periodontal ligament stem cells.Lasers in medical science · 2022Article
- Effects of Physical Stimulation in the Field of Oral Health.Scanning · 2021Review
- Review
- Effectiveness of Low-Level Laser Irradiation in Reducing Pain and Accelerating Socket Healing After Undisturbed Tooth Extraction.Journal of lasers in medical sciences · 2020Article
- The Effectiveness of the Low-Level Laser, Antibiotic and Surgical Therapy in the Treatment of Medication-Related Osteonecrosis of the Jaws: A Case Report.Journal of lasers in medical sciences · 2020Article
- Effect of Combined Application of Growth Factors and Diode Laser Bio-Stimulation on the Osseo Integration of Dental Implants.Open access Macedonian journal of medical sciences · 2019Article
- The influence of LLLT applied on applied on calvarial defect in rats under effect of cigarette smoke.Journal of applied oral science : revista FOB · 2019Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In our previous studies, we confirmed that low-level laser therapy (LLLT) with a 980-nm gallium-aluminum-arsenide diode laser was beneficial for the healing of the alveolar bone in rats with systemic disease. However, many factors can affect the biostimulatory effects of LLLT. Thus, we attempted to investigate the effects of irradiation time on the healing of extraction sockets by evaluating the expressions of genes and proteins related to bone healing. The left and right first maxillary molars of 24 rats were extracted. Rats were randomly divided into four groups in which extraction sockets were irradiated for 0, 1, 2, or 5 min each day for 3 or 7 days. Specimens containing the sockets were examined using quantitative real-time reverse transcription polymerase chain reaction and western blotting. LLLT increased the expressions of all tested genes, Runx2, collagen type 1, osteocalcin, platelet-derived growth factor-B, and vascular endothelial growth factor, in a time-dependent manner. The highest levels of gene expressions were in the 5-min group after 7 days. Five minutes of irradiation caused prominent increases of the expression of all tested proteins after both 3 and 7 days. The expression level of each protein in group 4 was higher by almost twofold compared with group 1 after 7 days. Laser irradiation for 5 min caused the highest expressions of genes and proteins related to bone healing. In conclusion, LLLT had positive effects on the early stages of bone healing of extraction sockets in rats, which were irradiation time-dependent.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.