Evidence map›Paper›PMID 23929546›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2014

Altered resting-state functional connectivity of basolateral and centromedial amygdala complexes in posttraumatic stress disorder.

Vanessa M Brown, Kevin S LaBar, Courtney C Haswell, Andrea L Gold, Mid-Atlantic MIRECC Workgroup, Gregory McCarthy, Rajendra A Morey

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 158 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
158citing papers in PubMed, 6 pooled it
11.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

158 citing papers in PubMed, 6 syntheses or guidelines pooled it, 272 citations in OpenAlex.

  1. Pooled it
  2. Neural Underpinnings of Social Stress in Substance Use Disorders.Current topics in behavioral neurosciences · 2022
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  10. Intranasal Oxytocin Normalizes Amygdala Functional Connectivity in Posttraumatic Stress Disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016
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  12. Blocking the mineralocorticoid receptor in humans prevents the stress-induced enhancement of centromedial amygdala connectivity with the dorsal striatum.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015
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  17. Mechanistic signatures of comorbid PTSD with cognitive impairment implicate cortisol-induced neural toxicity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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98 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Vanessa M Brown1] Mid-Atlantic MIRECC, Durham VA Medical Center, Durham VA, Durham, NC, USA [2] Duke-UNC Brain Imaging and Analysis Center, Duke University, Durham, NC, USA.
Kevin S LaBar1] Department of Psychology and Neuroscience, Duke University, Durham, NC, USA [2] Center for Cognitive Neuroscience, Duke University, Durham, NC, USA.
Courtney C Haswell1] Mid-Atlantic MIRECC, Durham VA Medical Center, Durham VA, Durham, NC, USA [2] Duke-UNC Brain Imaging and Analysis Center, Duke University, Durham, NC, USA.
Andrea L GoldDepartment of Psychology, Yale University, New Haven, CT, USA.
Mid-Atlantic MIRECC Workgroup
Gregory McCarthy1] Mid-Atlantic MIRECC, Durham VA Medical Center, Durham VA, Durham, NC, USA [2] Department of Psychology, Yale University, New Haven, CT, USA.
Rajendra A Morey1] Mid-Atlantic MIRECC, Durham VA Medical Center, Durham VA, Durham, NC, USA [2] Duke-UNC Brain Imaging and Analysis Center, Duke University, Durham, NC, USA [3] Center for Cognitive Neuroscience, Duke University, Durham, NC, USA [4] Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA.
Duke University · USDurham VA Medical Center · USYale University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The amygdala is a major structure that orchestrates defensive reactions to environmental threats and is implicated in hypervigilance and symptoms of heightened arousal in posttraumatic stress disorder (PTSD). The basolateral and centromedial amygdala (CMA) complexes are functionally heterogeneous, with distinct roles in learning and expressing fear behaviors. PTSD differences in amygdala-complex function and functional connectivity with cortical and subcortical structures remain unclear. Recent military veterans with PTSD (n=20) and matched trauma-exposed controls (n=22) underwent a resting-state fMRI scan to measure task-free synchronous blood-oxygen level dependent activity. Whole-brain voxel-wise functional connectivity of basolateral and CMA seeds was compared between groups. The PTSD group had stronger functional connectivity of the basolateral amygdala (BLA) complex with the pregenual anterior cingulate cortex (ACC), dorsomedial prefrontal cortex, and dorsal ACC than the trauma-exposed control group (p<0.05; corrected). The trauma-exposed control group had stronger functional connectivity of the BLA complex with the left inferior frontal gyrus than the PTSD group (p<0.05; corrected). The CMA complex lacked connectivity differences between groups. We found PTSD modulates BLA complex connectivity with prefrontal cortical targets implicated in cognitive control of emotional information, which are central to explanations of core PTSD symptoms. PTSD differences in resting-state connectivity of BLA complex could be biasing processes in target regions that support behaviors central to prevailing laboratory models of PTSD such as associative fear learning. Further research is needed to investigate how differences in functional connectivity of amygdala complexes affect target regions that govern behavior, cognition, and affect in PTSD.

Indexed as

Magnetic Resonance ImagingAdultAmygdalaFemaleHumansMaleMiddle AgedNerve NetNeural PathwaysRestStress Disorders, Post-Traumatic

Identifiers

PMID23929546
PMCPMC3870774
OpenAlexW2002801119

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.