Evidence map›Paper›PMID 23929545›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2014

Abnormalities in white matter microstructure associated with chronic ketamine use.

R Edward Roberts, H Valerie Curran, Karl J Friston, Celia J A Morgan

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.

  1. Pooled it
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  10. Ketamine plus Alcohol: What We Know and What We Can Expect about This.International journal of molecular sciences · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

R Edward RobertsClinical Psychopharmacology Unit, Research Department of Clinical Psychology, University College London, London, UK.
H Valerie CurranClinical Psychopharmacology Unit, Research Department of Clinical Psychology, University College London, London, UK.
Karl J FristonWellcome Trust Centre for Neuroimaging, University College London, London, UK.
Celia J A Morgan1] Clinical Psychopharmacology Unit, Research Department of Clinical Psychology, University College London, London, UK [2] Department of Psychology, University of Exeter, Exeter, UK.
University College London · GBUniversity of Exeter · GB

Funding

Wellcome Trust 088130Wellcome Trust 091593
6 · The paper itself

Abstract

Ketamine is an N-methyl-D-aspartate (NMDA) receptor antagonist that has been found to induce schizophrenia-type symptoms in humans and is a potent and fast-acting antidepressant. It is also a relatively widespread drug of abuse, particularly in China and the UK. Acute administration has been well characterized, but the effect of extended periods of ketamine use-on brain structure in humans-remains poorly understood. We measured indices of white matter microstructural integrity and connectivity in the brain of 16 ketamine users and 16 poly-drug-using controls, and we used probabilistic tractography to quantify changes in corticosubcortical connectivity associated with ketamine use. We found a reduction in the axial diffusivity profile of white matter in a right hemisphere network of white matter regions in ketamine users compared with controls. Within the ketamine-user group, we found a significant positive association between the connectivity profile between the caudate nucleus and the lateral prefrontal cortex and dissociative experiences. These findings suggest that chronic ketamine use may be associated with widespread disruption of white matter integrity, and white matter pathways between subcortical and prefrontal cortical areas may in part predict individual differences in dissociative experiences due to ketamine use.

Indexed as

AdultBrain ChemistryChronic DiseaseDiffusion Tensor ImagingFemaleHumansKetamineMaleMiddle AgedNerve Fibers, MyelinatedSubstance-Related DisordersYoung AdultKetamine

Identifiers

PMID23929545
PMCPMC3870785
OpenAlexW1981939133

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.