ArticleThe European physical journal. E, Soft matter2013
Multicellular aggregates: a model system for tissue rheology.
Article in The European physical journal. E, Soft matter, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Massart iron oxide nanoparticles in mechanobiology.Nanoscale advances · 2026Review
- Design and optimization of in situ self-functionalizing stress sensors.The European physical journal. E, Soft matter · 2026Article
- Structural-Scaling Transitions and Criticality Cascade in DNA with Open States.International journal of molecular sciences · 2025Article
- Compression of a pressurized spherical shell by a spherical or flat probe.The European physical journal. E, Soft matter · 2022Article
- Effect of liquid flow by pipetting during medium change on deformation of hiPSC aggregates.Regenerative therapy · 2019Article
- On the morphological stability of multicellular tumour spheroids growing in porous media.The European physical journal. E, Soft matter · 2016Article
- Colloquium: Mechanical formalisms for tissue dynamics.The European physical journal. E, Soft matter · 2015Article
- Assemblages: functional units formed by cellular phase separation.The Journal of cell biology · 2014Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Morphogenetic processes involve cell flows. The mechanical response of a tissue to active forces is linked to its effective viscosity. In order to decouple this mechanical response from the complex genetic changes occurring in a developing organism, we perform rheometry experiments on multicellular aggregates, which are good models for tissues. We observe a cell softening behavior when submitting to stresses. As our technique is very sensitive, we were able to get access to the measurement of a yield point above which a creep regime is observed obtained for strains above 12%. To explain our rheological curves we propose a model for the cytoskeleton that we represent as a dynamic network of parallel springs, which will break under stress and reattach at null strain. Such a simple model is able to reproduce most of the important behavior of cells under strain. We highlight here the importance of considering cells as complex fluids whose properties will vary with time according to the history of applied stress.
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Registered trials
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