ArticleBrain structure & function2014
Multi-region hemispheric specialization differentiates human from nonhuman primate brain function.
Article in Brain structure & function, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analytic evidence for a core problem solving network across multiple representational domains.Neuroscience and biobehavioral reviews · 2018Pooled it
- Comparative Analysis of Human-Chimpanzee Divergence in Brain Connectivity and its Genetic Correlates.bioRxiv : the preprint server for biology · 2024Article
- Effects of Anesthesia on Cerebral Blood Flow and Functional Connectivity of Nonhuman Primates.Veterinary sciences · 2022Review
- Is there hemispheric specialization in the chronic pain brain?Experimental neurology · 2022Review
- Is it left or is it right? A classification approach for investigating hemispheric differences in low and high dimensionality.Brain structure & function · 2022Article
- Combining brain perturbation and neuroimaging in non-human primates.NeuroImage · 2021Review
- Differential functional connectivity underlying asymmetric reward-related activity in human and nonhuman primates.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Brain executive laterality and hemisity.Personality neuroscience · 2020Article
- Inferring Cortical Connectivity from ECoG Signals Using Graph Signal Processing.IEEE access : practical innovations, open solutions · 2019Article
- Comparison of heritability estimates on resting state fMRI connectivity phenotypes using the ENIGMA analysis pipeline.Human brain mapping · 2018Article
- Article
- Structural asymmetry of the human cerebral cortex: Regional and between-subject variability of surface area, cortical thickness, and local gyrification.Neuropsychologia · 2016Article
- Evolutionary and developmental implications of asymmetric brain folding in a large primate pedigree.Evolution; international journal of organic evolution · 2016Article
- Resting-state functional connectivity in the baboon model of genetic generalized epilepsy.Epilepsia · 2015Article
- Robust Long-Range Coordination of Spontaneous Neural Activity in Waking, Sleep and Anesthesia.Cerebral cortex (New York, N.Y. : 1991) · 2015Article
- Functional connectivity architecture of the human brain: not all the same.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2014Article
- Functional specialization in the human brain estimated by intrinsic hemispheric interaction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Why primate models matter.American journal of primatology · 2014Review
- Modular structure facilitates mosaic evolution of the brain in chimpanzees and humans.Nature communications · 2014Article
- Primate comparative neuroscience using magnetic resonance imaging: promises and challenges.Frontiers in neuroscience · 2014Review
Corrections and comments
- Erratum issuedBlangero, John [added]
Authors and funding
10 authors.
Funding
Abstract
The human behavioral repertoire greatly exceeds that of nonhuman primates. Anatomical specializations of the human brain include an enlarged neocortex and prefrontal cortex (Semendeferi et al. in Am J Phys Anthropol 114:224-241, 2001), but regional enlargements alone cannot account for these vast functional differences. Hemispheric specialization has long believed to be a major contributing factor to such distinctive human characteristics as motor dominance, attentional control and language. Yet structural cerebral asymmetries, documented in both humans and some nonhuman primate species, are relatively minor compared to behavioral lateralization. Identifying the mechanisms that underlie these functional differences remains a goal of considerable interest. Here, we investigate the intrinsic connectivity networks in four primate species (humans, chimpanzees, baboons, and capuchin monkeys) using resting-state fMRI to evaluate the intra- and inter- hemispheric coherences of spontaneous BOLD fluctuation. All three nonhuman primate species displayed lateralized functional networks that were strikingly similar to those observed in humans. However, only humans had multi-region lateralized networks, which provide fronto-parietal connectivity. Our results indicate that this pattern of within-hemisphere connectivity distinguishes humans from nonhuman primates.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.