ArticleActa biomaterialia2013
The importance of size-exclusion characteristics of type I collagen in bonding to dentin matrices.
Article in Acta biomaterialia, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 74 citations in OpenAlex.
- Effect of root dentin pretreatment with different concentrations of chitosan on the push-out bond strength of fiber post using a self-adhesive resin cement.BMC oral health · 2025Article
- Theaflavin -3,3'-digallate/ethanol: a novel cross-linker for stabilizing dentin collagen.Frontiers in bioengineering and biotechnology · 2024Article
- Article
- Effect of polyhydroxy-terminated PAMAM dendrimer on dentin matrix metalloproteinases within the hybrid layers.BMC oral health · 2023Article
- EDTA-chitosan is a feasible conditioning agent for dentin bonding.Clinical oral investigations · 2022Article
- A novel dentin bonding scheme based on extrafibrillar demineralization combined with covalent adhesion using a dry-bonding technique.Bioactive materials · 2021Article
- A matched irrigation and obturation strategy for root canal therapy.Scientific reports · 2021Article
- Effect of accelerated aging and double application on the dentin bond strength of universal adhesive system.Dental research journal · 2021Article
- Doping bioactive elements into a collagen scaffold based on synchronous self-assembly/mineralization for bone tissue engineering.Bioactive materials · 2020Article
- Collagen intrafibrillar mineralization as a result of the balance between osmotic equilibrium and electroneutrality.Nature materials · 2017Article
- Modifications in Glass Ionomer Cements: Nano-Sized Fillers and Bioactive Nanoceramics.International journal of molecular sciences · 2016Review
- Dental adhesives and strategies for displacement of water/solvents from collagen fibrils.Dental materials : official publication of the Academy of Dental Materials · 2016Article
- Improved secondary caries resistance via augmented pressure displacement of antibacterial adhesive.Scientific reports · 2016Article
- The effects of ethanol on the size-exclusion characteristics of type I dentin collagen to adhesive resin monomers.Acta biomaterialia · 2016Article
- Effect of pretreatment with collagen crosslinkers on dentin protease activity.Dental materials : official publication of the Academy of Dental Materials · 2015Article
- Water distribution in dentin matrices: bound vs. unbound water.Dental materials : official publication of the Academy of Dental Materials · 2015Article
Corrections and comments
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Authors and funding
14 authors at 10 institutions in 6 countries.
Funding
Abstract
The mineral phase of dentin is located primarily within collagen fibrils. During development, bone or dentin collagen fibrils are formed first and then water within the fibril is replaced with apatite crystallites. Mineralized collagen contains very little water. During dentin bonding, acid-etching of mineralized dentin solubilizes the mineral crystallites and replaces them with water. During the infiltration phase of dentin bonding, adhesive comonomers are supposed to replace all of the collagen water with adhesive monomers that are then polymerized into copolymers. The authors of a recently published review suggested that dental monomers were too large to enter and displace water from collagen fibrils. If that were true, the endogenous proteases bound to dentin collagen could be responsible for unimpeded collagen degradation that is responsible for the poor durability of resin-dentin bonds. The current work studied the size-exclusion characteristics of dentin collagen, using a gel-filtration-like column chromatography technique, using dentin powder instead of Sephadex. The elution volumes of test molecules, including adhesive monomers, revealed that adhesive monomers smaller than ∼1000 Da can freely diffuse into collagen water, while molecules of 10,000 Da begin to be excluded, and bovine serum albumin (66,000 Da) was fully excluded. These results validate the concept that dental monomers can permeate between collagen molecules during infiltration by etch-and-rinse adhesives in water-saturated matrices.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.