Evidence map›Paper›PMID 23928196›Full record

ReviewNeuroimaging clinics of North America2013

Magnetic resonance spectroscopy in common dementias.

Kejal Kantarci

Open access · greenAbstract readReview
In one paragraph

Review in Neuroimaging clinics of North America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 46 citations in OpenAlex.

  1. Magnetic Resonance Spectroscopy (MRS) in Alzheimer's Disease.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  2. Article
  3. Article
  4. Molecules (Basel, Switzerland) · 2021
    Article
  5. Article
  6. Application ofBMC nephrology · 2020
    Article
  7. Article
  8. Review
  9. Frontal lobeNeurology · 2019
    Article
  10. Article
  11. Review
  12. Review
  13. mNos2 deletion and human NOS2 replacement in Alzheimer disease models.Journal of neuropathology and experimental neurology · 2014
    Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Kejal KantarciDivision of Neuroradiology, Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA. kantarci.kejal@mayo.edu
Mayo Clinic · US

Funding

THE PGRN/TDP-43 AXIS IN ALZHEIMER?S DISEASE AND NEURODEGENERATIONP50AG016574 · NIA · MAYO CLINIC ROCHESTER · PI LUCAS, JOHN · 1999 to 2018
$36.9M
Sex-specific Risk for Vascular Dysfunction and Cognitive DeclineP50AG044170 · NIA · MAYO CLINIC ROCHESTER · PI MILLER, VIRGINIA M · 2012 to 2017
$6.1M
Pathological basis of MRS and DTI changes in neurodegenerative dementiaR01AG040042 · NIA · MAYO CLINIC ROCHESTER · PI KANTARCI, KEJAL · 2011 to 2015
$1.6M
1H MRS markers of MCI syndromes and common dementiasK23AG030935 · NIA · MAYO CLINIC ROCHESTER · PI KANTARCI, KEJAL · 2007 to 2009
$630k
Effects of estrogen on brain morphology and neuronal integrity in early menopauseR21NS066147 · NINDS · MAYO CLINIC ROCHESTER · PI KANTARCI, KEJAL · 2010 to 2011
$405k
NIA NIH HHS K23 AG030935NIA NIH HHS P50 AG016574NIA NIH HHS P50 AG044170NIA NIH HHS P50 AG16574/PROJECT1NIA NIH HHS R01 AG040042NIA NIH HHS R01 AG40042NINDS NIH HHS R21 NS066147
6 · The paper itself

Abstract

Neurodegenerative dementias are characterized by elevated myoinositol and decreased N-acetylaspartate (NAA) levels. The increase in myoinositol seems to precede decreasing NAA levels in Alzheimer's diseases. NAA/myo-inositol ratio in the posterior cingulate gyri decreases with increasing burden of Alzheimer's disease pathologic conditions. Proton magnetic resonance spectroscopy ((1)H MRS) is sensitive to the pathophysiologic processes associated with the risk of dementia in patients with mild cognitive impairment. Although significant progress has been made in improving the acquisition and analysis techniques in (1)H MRS, translation of these technical developments to clinical practice have not been effective because of the lack of standardization for multisite applications and normative data and an insufficient understanding of the pathologic basis of (1)H MRS metabolite changes.

Indexed as

Aspartic AcidBiomarkersBrainDementiaHumansInositolMagnetic Resonance SpectroscopyAspartic AcidBiomarkersInositolN-acetylaspartateAlzheimer’s diseaseDementiasMagnetic resonance spectroscopyMild cognitive impairmentN-Acetylaspartate

Identifiers

PMID23928196
PMCPMC3748940
OpenAlexW2082505510

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.