Evidence map›Paper›PMID 23928091›Full record

ArticleJournal of the American Society of Echocardiography : official publication of the American Society of Echocardiography2013

Tricuspid annular plane systolic excursion in the assessment of right ventricular function in children and adolescents after repair of tetralogy of Fallot.

Laura Mercer-Rosa, Aimee Parnell, Paul R Forfia, Wei Yang, Elizabeth Goldmuntz, Steven M Kawut

Abstract read
In one paragraph

Article in Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 89 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Laura Mercer-RosaDivision of Cardiology, Department of Pediatrics, The Children's Hospital of Philadelphia and the Perelman School of Medicine, Philadelphia, Pennsylvania; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address: mercerrosal@email.chop.edu.
Aimee Parnell
Paul R Forfia
Wei Yang
Elizabeth Goldmuntz
Steven M Kawut
University of Pennsylvania · USChildren's Hospital of Philadelphia · USUniversity of Mississippi · US

Funding

Molecular Analysis of Human Subtelomeric RearrangementsP50HL074731 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI RYAN, KENNETH · 2004 to 2008
$19.2M
Pediatric Hospital Epidemiology and Outcomes Research Training ProgramT32HD060550 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI Christopher Peter Bonafide, John Chris Feudtner · 2010 to 2026
$6.8M
Mentored Patient-Oriented Research in Pulmonary Arterial HypertensionK24HL103844 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KAWUT, STEVEN M · 2011 to 2020
$1.6M
NHLBI NIH HHS K24 HL103844NHLBI NIH HHS K24-HL103844NHLBI NIH HHS P50 HL074731NHLBI NIH HHS P50-HL74731NICHD NIH HHS T32 HD060550
6 · The paper itself

Abstract

backgroundAssessing right ventricular (RV) performance is essential for patients with tetralogy of Fallot (TOF). The aim of this study was to investigate the reliability and validity of tricuspid annular plane systolic excursion (TAPSE) against cardiac magnetic resonance imaging measures and cardiopulmonary exercise testing.

methodsA retrospective study was performed in 125 outpatients with repaired TOF with available protocol-driven echocardiography, cardiac magnetic resonance imaging, and exercise stress testing obtained as part of a cross-sectional study. TAPSE was measured on the two-dimensional apical four-chamber view on echocardiography by two readers. Multivariate linear regression was used to examine the association between TAPSE and measures of RV function and exercise capacity.

resultsThe mean age was 12.6 ± 3.3 years, 41 patients (33%) were female, and 104 (83%) were white. TAPSE averaged 1.6 ± 0.37 cm, with an interreader intraclass correlation coefficient of 0.78 (n = 18). TAPSE was significantly associated with cardiac magnetic resonance-based RV stroke volume after adjustment for gender and body surface area (β = 13.8; 95% confidence interval, 2.25-25.30; P = .02). TAPSE was not associated with cardiac magnetic resonance-based RV ejection fraction (P = .77). On exercise testing, TAPSE was not associated with peak oxygen consumption, percentage of predicted oxygen consumption, oxygen pulse, or the ventilatory equivalent for carbon dioxide in patients with maximal exercise stress testing (n = 73 [58%]).

conclusionsTAPSE is reproducibly measured by echocardiography in patients with TOF. It is not associated with RV ejection fraction or exercise performance, and its association with RV stroke volume may be confounded by body size. On the basis of these results, TAPSE is not representative of global RV performance in patients with TOF.

Indexed as

AdolescentAdultChildEchocardiographyExercise TestFemaleHumansMalePrognosisReproducibility of ResultsRetrospective StudiesSensitivity and SpecificityTetralogy of FallotTreatment OutcomeTricuspid ValveVentricular Dysfunction, Right2DBody surface areaBSACarbon dioxide productionCardiac magnetic resonanceCICMRConfidence intervalEchocardiographyESTExerciseExercise stress testingICCIntraclass correlation coefficientMagnetic resonance imagingOxygen consumptionPredicted percentage of maximum oxygen consumptionRight ventricularRight ventricular ejection fractionRight ventricular end-diastolic volumeRight ventricular end-systolic volumeRVRVEDVRVEFRVESVTAPSETetralogy of FallotTOFTricuspid annular plane systolic excursionTwo-dimensionalVco(2)Ventilatory equivalent of carbon dioxideVE/Vco(2)Vo(2)Vo(2)max%

Identifiers

PMID23928091
PMCPMC4336673
OpenAlexW2090695432

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.