ArticleThe Journal of antimicrobial chemotherapy2013
Association of norB overexpression and fluoroquinolone resistance in clinical isolates of Staphylococcus aureus from Korea.
Article in The Journal of antimicrobial chemotherapy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 68 citations in OpenAlex.
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- Antimicrobial susceptibility and adaptative changes in MRSA lineages exposed to increasing concentrations of fluoroquinolones and chlorhexidine.Scientific reports · 2026Article
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- NorA and Tet38 efflux pumps enableAntimicrobial agents and chemotherapy · 2025Article
- Mechanisms ofInternational journal of molecular sciences · 2025Article
- Fluoroquinolone resistance in ESKAPE pathogens: evolutionary pathways, one health transmission, and clinical surveillance.Frontiers in microbiology · 2025Review
- Genomic and Phenotypic Characterization of Mastitis-Causing Staphylococci and Probiotic Lactic Acid Bacteria Isolated from Raw Sheep's Milk.International journal of molecular sciences · 2023Article
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- Anti-hepatitis C virus drug simeprevir: a promising antimicrobial agent against MRSA.Applied microbiology and biotechnology · 2022Article
- In Vivo and In Vitro Antimicrobial Activity of Biogenic Silver Nanoparticles againstPharmaceuticals (Basel, Switzerland) · 2022Article
- The Genetic Relatedness and Antimicrobial Resistance Patterns of Mastitis-CausingVeterinary sciences · 2021Article
- Comparative Transcriptomic Analysis of Staphylococcus aureus Associated with Periprosthetic Joint Infection under in Vivo and in Vitro Conditions.The Journal of molecular diagnostics : JMD · 2021Article
- Elucidation of Phytochemical Content ofAntibiotics (Basel, Switzerland) · 2021Article
- The Whole Is Bigger than the Sum of Its Parts: Drug Transport in the Context of Two Membranes with Active Efflux.Chemical reviews · 2021Article
- Whole Genome Sequencing of Staphylococci Isolated From Bovine Milk Samples.Frontiers in microbiology · 2021Article
- Genome-Wide Association Studies for the Detection of Genetic Variants Associated With Daptomycin and Ceftaroline Resistance inFrontiers in microbiology · 2021Article
- Antimicrobial resistance monitoring of commensal Enterococcus faecalis in broiler breeders.Poultry science · 2020Article
- The Persister Character of Clinical Isolates ofFrontiers in microbiology · 2020Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
objectivesAlthough the prevalence of fluoroquinolone resistance among methicillin-resistant Staphylococcus aureus (MRSA) is known to be higher than in methicillin-susceptible S. aureus (MSSA), the reasons have never been identified.
methodsWe randomly selected 115 isolates of S. aureus collected from 10 different hospitals in Korea between June 2009 and May 2011. To investigate the difference in fluoroquinolone resistance mechanisms between MRSA and MSSA, we evaluated gyrA and parC mutations and the relative expression of the multidrug efflux pump genes norA, norB and norC.
resultsAll 62 ciprofloxacin-resistant S. aureus had either gyrA or parC mutations. The S84L mutation of gyrA (59/62, 95.2%) and the S80F mutation of parC (61/62, 98.4%) were the most common. Fifty-eight (93.6%) strains had both the S84L mutation of gyrA and the S80F mutation of parC. Among the 115 isolates, norB overexpression was the most common, occurring in 49 (42.6%) strains. There were only two (1.7%) strains with norA overexpression and none with norC overexpression. Strains overexpressing norB were more common among ciprofloxacin-resistant S. aureus (33/62, 53.2%) than ciprofloxacin-susceptible S. aureus (16/53, 30.2%) (P = 0.013). When we analysed 62 ciprofloxacin-resistant S. aureus strains, those overexpressing norB were more common in ciprofloxacin-resistant MRSA (28/46, 60.9%) than in ciprofloxacin-resistant MSSA (5/16, 31.3%) (P = 0.041).
conclusionsIncreased expression of norB can be a factor that contributes to ciprofloxacin resistance in MRSA strains.
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