ArticleMolecular biology and evolution2013
The population genomics of repeated evolution in the blind cavefish Astyanax mexicanus.
Article in Molecular biology and evolution, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 90 citations in OpenAlex.
- Exploring Astyanax mexicanus as a model for unraveling genotype-environment interactions and metabolic adaptations.Lab animal · 2026Review
- Beyond Mendel: a call to revisit the genotype-phenotype map through new experimental paradigms.Genetics · 2026Article
- Widespread loss of sleep in independently evolved populations of wild-caught cavefish.iScience · 2025Article
- Fine-tuning GBS data with comparison of reference and mock genome approaches for advancing genomic selection in less studied farmed species.BMC genomics · 2025Article
- The spatiotemporal and genetic architecture of extraoral taste buds in Astyanax cavefish.Communications biology · 2024Article
- From darkness to discovery: evolutionary, adaptive, and translational genetic insights from cavefish.Trends in genetics : TIG · 2024Review
- Variable Craniofacial Shape and Development among Multiple Cave-Adapted Populations ofIntegrative organismal biology (Oxford, England) · 2024Article
- Article
- Convergence on reduced aggression through shared behavioral traits in multiple populations of Astyanax mexicanus.BMC ecology and evolution · 2022Article
- Genome-wide analysis of cis-regulatory changes underlying metabolic adaptation of cavefish.Nature genetics · 2022Article
- From Cave Dragons to Genomics: Advancements in the Study of Subterranean Tetrapods.Bioscience · 2022Article
- Evolutionary and homeostatic changes in morphology of visual dendrites of Mauthner cells in Astyanax blind cavefish.The Journal of comparative neurology · 2021Article
- Evolution in Sinocyclocheilus cavefish is marked by rate shifts, reversals, and origin of novel traits.BMC ecology and evolution · 2021Article
- Systemic paralogy and function of retinal determination network homologs in arachnids.BMC genomics · 2020Article
- Retinal morphology in Astyanax mexicanus during eye degeneration.The Journal of comparative neurology · 2020Article
- Signatures of selection for bonamiosis resistance in European flat oyster (Evolutionary applications · 2019Article
- An Adult Brain Atlas Reveals Broad Neuroanatomical Changes in Independently Evolved Populations of Mexican Cavefish.Frontiers in neuroanatomy · 2019Article
- Sperm swimming behaviors are correlated with sperm haploid genetic variability in the Mexican tetra, Astyanax mexicanus.PloS one · 2019Article
- The role of gene flow in rapid and repeated evolution of cave-related traits in Mexican tetra, Astyanax mexicanus.Molecular ecology · 2018Article
- Population genomics of parallel evolution in gene expression and gene sequence during ecological adaptation.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Distinct populations of Astyanax mexicanus cavefish offer striking examples of repeatable convergence or parallelism in their independent evolutions from surface to cave phenotypes. However, the extent to which the repeatability of evolution occurred at the genetic level remains poorly understood. To address this, we first characterized the genetic diversity of 518 single-nucleotide polymorphisms (SNPs), obtained through RAD tag sequencing and distributed throughout the genome, in seven cave and three groups of surface populations. The cave populations represented two distinct lineages (old and new). Thirty-one SNPs were significantly differentiated between surface and old cave populations, two SNPs were differentiated between surface and new cave populations, and 44 SNPs were significantly differentiated in both old and new cave populations. In addition, we determined whether these SNPs map to the same locations of previously described quantitative trait loci (QTL) between surface and cave populations. A total of 25 differentiated SNPs co-map with several QTL, such as one containing a fibroblast growth factor gene (Fgf8) involved in eye development and lens size. Further, the identity of many SNPs that co-mapped with QTL was the same in independently derived cave populations. These conclusions were further confirmed by haplotype analyses of SNPs within QTL regions. Our findings indicate that the repeatability of evolution at the genetic level is substantial, suggesting that ancestral standing genetic variation significantly contributed to the population genetic variability used in adaptation to the cave environment.
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