ArticleInvestigative ophthalmology & visual science2013
The role of macrophage class a scavenger receptors in a laser-induced murine choroidal neovascularization model.
Article in Investigative ophthalmology & visual science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- A human amelotin transgenic mouse model with calcified deposits similar to those in dry age-related macular degeneration.Experimental eye research · 2026Article
- Comparative Analysis of Molecular Landscape in Mouse Models and Patients Reveals Conserved Inflammation Pathways in Age-Related Macular Degeneration.Investigative ophthalmology & visual science · 2024Article
- Neovascular Progression and Retinal Dysfunction in the Laser-Induced Choroidal Neovascularization Mouse Model.Biomedicines · 2023Article
- Bacterial Cellulose as a Potential Bio-Scaffold for Effective Re-Epithelialization Therapy.Pharmaceutics · 2021Article
- Key Role of Microglial Matrix Metalloproteinases in Choroidal Neovascularization.Frontiers in cellular neuroscience · 2021Article
- Innate Immunity in Age-Related Macular Degeneration.Advances in experimental medicine and biology · 2021Article
- Amount of Mononuclear Phagocyte Infiltrate Does Not Predict Area of Experimental Choroidal Neovascularization (CNV).Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2018Article
- Activator protein-1 contributes to the NaCl-induced expression of VEGF and PlGF in RPE cells.Molecular vision · 2018Article
- Flt3 Regulation in the Mononuclear Phagocyte System Promotes Ocular Neovascularization.Journal of ophthalmology · 2018Article
- Monocyte chemoattractant protein 1 and fractalkine play opposite roles in angiogenesisInternational journal of ophthalmology · 2018Article
- Anti-complement component 5 antibody targeting MG4 domain inhibits choroidal neovascularization.Oncotarget · 2017Article
- Lymphocytic Microparticles Modulate Angiogenic Properties of Macrophages in Laser-induced Choroidal Neovascularization.Scientific reports · 2016Article
- Visible-Light Optical Coherence Tomography Angiography for Monitoring Laser-Induced Choroidal Neovascularization in Mice.Investigative ophthalmology & visual science · 2016Article
- A Mouse Model for Laser-induced Choroidal Neovascularization.Journal of visualized experiments : JoVE · 2015Article
- Choroidal neovascularization is inhibited via an intraocular decrease of inflammatory cells in mice lacking complement component C3.Scientific reports · 2015Article
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Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeLaser-induced choroidal neovascularization (CNV) is a widely used model to mimic many features of CNV resulting from wet AMD. Macrophages have been implicated in the pathogenesis of AMD. Class A scavenger receptors, scavenger receptor-A (SR-A) and macrophage receptor with collagenous domain (MARCO), are expressed on macrophages and are associated with macrophage function. The goal of this study is to examine the role of macrophage scavenger receptors in immune cell recruitment and the formation of CNV.
methodsLaser photocoagulation was performed in wild-type and knockout mice with deletion of SR-A (SR-A(-/-)), MARCO (MARCO(-/-)), or both SR-A and MARCO double knockout (DKO). Immune cell recruitment at different time points and CNV lesions at 14 days after laser treatment were evaluated through immunostaining and confocal microscopy. Microarray analysis was performed in eyes 1 day after laser injury.
resultsWild-type eyes showed higher chemokine/receptor expression compared with knockout eyes after laser injury. Scavenger receptor deficiency markedly impaired the recruitment of neutrophils and macrophages to CNV lesions at 1- and 3-days post laser injury, respectively. Significantly reduced CNV volumes were found in the eyes from scavenger receptor knockout mice compared with wild-type mice.
conclusionsThe deficiency of scavenger receptors impairs the formation of CNV and immune cell recruitment. Our findings suggest a potential role for scavenger receptors in contributing to CNV formation and inflammation in AMD.
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