SynthesisThe American journal of cardiology2013
Meta-analysis of ventricular premature complexes and their relation to cardiac mortality in general populations.
Synthesis in The American journal of cardiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
83 citing papers in PubMed, 5 syntheses or guidelines pooled it, 167 citations in OpenAlex.
- Brazilian Guideline for Exercise Test in the Adult Population - 2024.Arquivos brasileiros de cardiologia · 2024Guideline
- Association of premature ventricular complexes and risk of ischemic stroke: A systematic review and meta-analysis.Clinical cardiology · 2021Pooled it
- 2020 APHRS/HRS expert consensus statement on the investigation of decedents with sudden unexplained death and patients with sudden cardiac arrest, and of their families.Heart rhythm · 2021Guideline
- For Whom the Bell Tolls : Refining Risk Assessment for Sudden Cardiac Death.Current cardiology reports · 2019Pooled it
- Genome-wide association study and meta-analysis identify loci associated with ventricular and supraventricular ectopy.Scientific reports · 2018Pooled it
- Chinese Herbal Medicine Dingji Fumai Decoction for Ventricular Premature Contraction: A Real-World Trial.BioMed research international · 2020Trial
- Effect of Yoga on Ventricular Premature Complex Burden and Quality of Life: The VPC-Yoga Study.JACC. Advances · 2026Article
- Long-term survival in patients with premature ventricular complexes and no structural heart disease.Open heart · 2026Observational
- ECG and PPG Signals-Based Premature Ventricular Contraction Detection Methods: A Review, Key Challenges, and Future Directions.Cardiovascular engineering and technology · 2026Review
- Comprehensive cardiac magnetic resonance imaging in patients with idiopathic premature ventricular contractions: role of feature-tracking strain and T1/T2 mapping in detecting subclinical myocardial dysfunction.Quantitative imaging in medicine and surgery · 2026Article
- Time Course of Cardiac Arrhythmia Following High-Volume Exercise in Recreational Cyclists.Journal of the American Heart Association · 2026Article
- Effectiveness and safety of Guipi Mixture for the treatment of premature ventricular contractions (heart-spleen deficiency syndrome): study protocol for a randomized, double-blind, placebo-controlled, multicentre trial.Frontiers in cardiovascular medicine · 2026Article
- Knowledge, attitudes, and practices regarding premature ventricular contractions among patients: a cross-sectional study.Frontiers in public health · 2026Article
- Premature ventricular complexes and risk of atrial fibrillation and stroke in patients without structural heart disease.Heart (British Cardiac Society) · 2025Observational
- Electromechanical demonstration of premature ventricular contraction-induced atrial cardiomyopathy by P wave duration-to-amplitude ratio (PWDAR) and left atrial strain.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2025Article
- QT Prolongation Following Premature Ventricular Contractions Leading to Ventricular Storms: A Case Report.Cureus · 2025Article
- The Prevalence of Arrhythmias, Including Premature Supraventricular and Ventricular Beats and Other Electrocardiographic Patterns, in 24-Hour Holter Monitoring in Patients with Overweight and Obesity.Life (Basel, Switzerland) · 2024Article
- Classification of Premature Ventricular Contractions in Athletes During Routine Preparticipation Exams.Circulation. Arrhythmia and electrophysiology · 2024Article
- Role of Cardiac Magnetic Resonance in the Assessment of Patients with Premature Ventricular Contractions: A Narrative Review.Anatolian journal of cardiology · 2024Article
- Number of Premature Ventricular Complexes Predicts Long-Term Outcomes in Patients with Persistent Atrial Fibrillation.Biomedicines · 2024Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Although previous studies have shown that frequent ventricular premature complexes (VPCs) in patients with established heart disease are associated with increased risk of cardiac mortality, the significance of VPCs in general populations is unclear. The aim of this study was to assess the association between VPCs and risk of sudden cardiac death or total cardiac death in general populations by conducting a meta-analysis of published research. The electronic databases MEDLINE and Embase were searched for relevant studies. Data were abstracted using standardized forms. Study-specific relative risk estimates were pooled using a random-effects meta-analysis model. Eleven studies comprising a total of 106,195 participants sampled from general populations were included. Studies generally defined frequent VPCs as occurring ≥1 time during a standard electrocardiographic recording or ≥30 times over a 1-hour recording. The prevalence of frequent VPCs in the studies ranged from 1.2% to 10.7%. The overall adjusted relative risk for sudden cardiac death comparing participants with frequent VPCs versus those without frequent VPCs was 2.64 (95% confidence interval 1.93 to 3.63). The corresponding value for total cardiac death was 2.07 (95% confidence interval 1.71 to 2.50). Although most studies made attempts to exclude high-risk subjects, such as those with histories of cardiovascular disease, they did not test participants for underlying structural heart disease. In conclusion, findings from observational studies in general populations indicate that frequent VPCs are associated with a substantial increase in the risk for sudden cardiac death and total cardiac death. Further study is needed to determine the role of confounding and underlying structural heart disease in the observed association and its utility in cardiovascular risk prediction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.