ArticleGenes, brain, and behavior2013
Neurobiology of secure infant attachment and attachment despite adversity: a mouse model.
Article in Genes, brain, and behavior, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Possible roles of deep cortical neurons and oligodendrocytes in the neural basis of human sociality.Anatomical science international · 2024Review
- Local injury and systemic infection in infants alter later nociception and pain affect during early life and adulthood.Brain, behavior, & immunity - health · 2020Article
- Neural meaning making, prediction, and prefrontal-subcortical development following early adverse caregiving.Development and psychopathology · 2020Review
- The maturational characteristics of the GABA input in the anterior piriform cortex may also contribute to the rapid learning of the maternal odor during the sensitive period.Learning & memory (Cold Spring Harbor, N.Y.) · 2020Article
- Oxytocin receptor gene loss influences expression of the oxytocin gene in C57BL/6J mice in a sex- and age-dependent manner.Journal of neuroendocrinology · 2020Article
- Maturation of pyramidal cells in anterior piriform cortex may be sufficient to explain the end of early olfactory learning in rats.Learning & memory (Cold Spring Harbor, N.Y.) · 2020Article
- Resilience priming: Translational models for understanding resiliency and adaptation to early life adversity.Developmental psychobiology · 2019Review
- Unique infant neurobiology produces distinctive trauma processing.Developmental cognitive neuroscience · 2019Review
- Epigenetic Changes Associated with Early Life Experiences: Saliva, A Biospecimen for DNA Methylation Signatures.Current genomics · 2018Article
- Early life stress leads to developmental and sex selective effects on performance in a novel object placement task.Neurobiology of stress · 2017Article
- Chronic early life stress induced by limited bedding and nesting (LBN) material in rodents: critical considerations of methodology, outcomes and translational potential.Stress (Amsterdam, Netherlands) · 2017Article
- Emotional learning, stress, and development: An ever-changing landscape shaped by early-life experience.Neurobiology of learning and memory · 2017Review
- The neurobiology of safety and threat learning in infancy.Neurobiology of learning and memory · 2017Review
- Early life adversity during the infant sensitive period for attachment: Programming of behavioral neurobiology of threat processing and social behavior.Developmental cognitive neuroscience · 2017Review
- NMDA receptors in mouse anterior piriform cortex initialize early odor preference learning and L-type calcium channels engage for long-term memory.Scientific reports · 2016Article
- Ecologically relevant neurobehavioral assessment of the development of threat learning.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Review
- Changes in dam and pup behavior following repeated postnatal exposure to a predator odor (TMT): A preliminary investigation in Long-Evans rats.Developmental psychobiology · 2016Article
- Unique neurobiology during the sensitive period for attachment produces distinctive infant trauma processing.European journal of psychotraumatology · 2016Review
- Norepinephrine Modulates Pyramidal Cell Synaptic Properties in the Anterior Piriform Cortex of Mice: Age-Dependent Effects of β-adrenoceptors.Frontiers in cellular neuroscience · 2015Article
- Slow-wave sleep-imposed replay modulates both strength and precision of memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
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Authors and funding
13 authors.
Funding
Abstract
Attachment to an abusive caregiver has wide phylogenetic representation, suggesting that animal models are useful in understanding the neural basis underlying this phenomenon and subsequent behavioral outcomes. We previously developed a rat model, in which we use classical conditioning to parallel learning processes evoked during secure attachment (odor-stroke, with stroke mimicking tactile stimulation from the caregiver) or attachment despite adversity (odor-shock, with shock mimicking maltreatment). Here we extend this model to mice. We conditioned infant mice (postnatal day (PN) 7-9 or 13-14) with presentations of peppermint odor and either stroking or shock. We used (14) C 2-deoxyglucose (2-DG) to assess olfactory bulb and amygdala metabolic changes following learning. PN7-9 mice learned to prefer an odor following either odor-stroke or shock conditioning, whereas odor-shock conditioning at PN13-14 resulted in aversion/fear learning. 2-DG data indicated enhanced bulbar activity in PN7-9 preference learning, whereas significant amygdala activity was present following aversion learning at PN13-14. Overall, the mouse results parallel behavioral and neural results in the rat model of attachment, and provide the foundation for the use of transgenic and knockout models to assess the impact of both genetic (biological vulnerabilities) and environmental factors (abusive) on attachment-related behaviors and behavioral development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.