ArticleLangmuir : the ACS journal of surfaces and colloids2013
Capture and printing of fixed stromal cell membranes for bioactive display on PDMS surfaces.
Article in Langmuir : the ACS journal of surfaces and colloids, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Spatial Regulation of Mitochondrial Heterogeneity by Stromal Confinement in Micropatterned Tumor Models.Scientific reports · 2019Article
- Scaffold-integrated microchips for end-to-endTechnology · 2015Article
- Cancer-associated fibroblasts as target and tool in cancer therapeutics and diagnostics.Virchows Archiv : an international journal of pathology · 2015Review
- Bioengineered implantable scaffolds as a tool to study stromal-derived factors in metastatic cancer models.Cancer research · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Poly(dimethylsiloxane) (PDMS) has emerged as an extremely useful polymer for various biological applications. The conjugation of PDMS with bioactive molecules to create functional surfaces is feasible yet limited to a single-molecule display with imprecise localization of the molecules on PDMS. Here we report a robust technique that can transfer and print the membrane surface of glutaraldehyde-fixed stromal cells intact onto a PDMS substrate using an intermediate polyvinylalcohol (PVA) film as a transporter system. The cell-PVA film capturing the entirety of surface molecules can be peeled off and subsequently printed onto PDMS while maintaining the spatial display of the original cell surface molecules. Proof-of-concept studies are described using human bone marrow stromal cell membranes including a demonstration of the bioactivity of transferred membranes to capture and adhere hematopoietic cells. The presented process is applicable to virtually any adherent cell and can broaden the functional display of biomolecules on PDMS for biotechnology applications.
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Registered trials
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