ArticleDevelopmental medicine and child neurology2013
Comparison of Bayley-2 and Bayley-3 scores at 18 months in term infants following neonatal encephalopathy and therapeutic hypothermia.
Article in Developmental medicine and child neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Incidence and outcomes of intrapartum-related neonatal encephalopathy in low-income and middle-income countries: a systematic review and meta-analysis.BMJ global health · 2022Pooled it
- Developmental outcomes after early surgery for complex congenital heart disease: a systematic review and meta-analysis.Developmental medicine and child neurology · 2021Pooled it
- Neurodevelopmental outcome in infants with neonatal encephalopathy receiving hydrocortisone during therapeutic hypothermia: follow-up of the extended-CORTISoL trial.Journal of perinatology : official journal of the California Perinatal Association · 2025Trial
- Prediction of outcome from MRI and general movements assessment after hypoxic-ischaemic encephalopathy in low-income and middle-income countries: data from a randomised controlled trial.Archives of disease in childhood. Fetal and neonatal edition · 2022Trial
- Trial
- No neurodevelopmental benefit of cerebral oximetry in the first randomised trial (SafeBoosC II) in preterm infants during the first days of life.Acta paediatrica (Oslo, Norway : 1992) · 2019Trial
- Trial
- Trial
- Risk Factors Influencing Neurodevelopmental Outcome and Survival in Preterm Infants: A Prospective Cohort Study.Children (Basel, Switzerland) · 2026Article
- Association of early biochemical markers with in-hospital mortality in infants with neonatal encephalopathy.Pediatric research · 2026Article
- Metabolic expenditure, neurodevelopment, and weight gain into early childhood after fetal growth restriction.Scientific reports · 2026Article
- Early developmental intervention and neurodevelopmental trajectories in preterm infants without severe brain injury.Pediatric research · 2026Article
- Beneficial Effects and Factors Associated With Provision of Breast Milk at Neonatal Intensive Care Unit Discharge to Very Low Birth Weight Infants: A Nationwide Cohort Study in Korea.Journal of Korean medical science · 2026Article
- Cognitive development at late infancy and school age in children cooled for neonatal encephalopathy.Pediatric research · 2026Article
- Association between cardiovascular care and neurodevelopmental outcomes in infants with neonatal encephalopathy and hemodynamic instability.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- End-Tidal Carbon Dioxide Monitoring in Neonates Receiving Therapeutic Hypothermia for Hypoxic-Ischemic Encephalopathy.Pediatric pulmonology · 2025Observational
- Elevated cerebral perfusion in neonatal encephalopathy is associated with neurodevelopmental impairments.Pediatric research · 2025Article
- Prematurity is associated with white matter T2 MRI visible perivascular spaces in very preterm-born neonates.Brain communications · 2025Article
- Posterior subependymal germinal matrix hemorrhage as a mild form of hemorrhage in extremely preterm infants: neurodevelopmental outcomes at corrected ages of 18-24 months.Ultrasonography (Seoul, Korea) · 2025Article
- Altered Connectome Topology in Newborns at Risk for Cognitive Developmental Delay: A Cross-Etiologic Study.Human brain mapping · 2025Article
Corrections and comments
- Commented on by
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimNeuroprotection trials for neonatal encephalopathy use moderate or severe disability as an outcome, with the Bayley Scales of Infant Development, Second Edition (Bayley-2) Index scores of <70 as part of the criteria. The Bayley Scales of Infant and Toddler, 3rd Development, Third Edition (Bayley-3) have superseded Bayley-2 and yield higher than expected scores in typically developing and high-risk infants. The aim of this study, therefore, was to compare Bayley-2 scores and Bayley-3 scores in term-born infants surviving neonatal encephalopathy treated with hypothermia.
methodSixty-one term-born infants (37 males, 24 females; median gestational age at birth 40 wks, range 36-42 wks; median birthweight 3280 g, range 2295-5050) following neonatal encephalopathy and hypothermia had contemporaneous assessment at 18 months using the Bayley-2 and Bayley-3.
resultsThe median Bayley-3 Cognitive Composite score was 7 points higher than the median Bayley-2 Mental Developmental Index (MDI) score and the median Bayley-3 Motor Composite score was 18 points higher than the median Bayley-2 Psychomotor Developmental Index (PDI) score. Ten children had a Bayley-2 MDI of <70; only three children had Bayley-3 combined Cognitive/Language scores of <70. Eleven children had Bayley-2 PDI scores of <70 and four had modified Bayley-3 Motor Composite scores of <70. Applying regression equations to Bayley-3 scores adjusted rates of severe delay to similar proportions found using Bayley-2 scores.
interpretationFewer children were classified with severe delay using the Bayley-3 than the Bayley-2, which prohibits direct comparison of scores. Increased Bayley-3 cut-off thresholds for classifying severe disability are recommended when comparing studies in this clinical group using Bayley-2 scores.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.