Evidence map›Paper›PMID 23927507›Full record

ArticleAmerican journal of public health2013

Genetic differential sensitivity to social environments: implications for research.

Colter Mitchell, Sara McLanahan, Jeanne Brooks-Gunn, Irwin Garfinkel, John Hobcraft, Daniel Notterman

Abstract read
In one paragraph

Article in American journal of public health, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  18. Article
  19. Social disadvantage, genetic sensitivity, and children's telomere length.Proceedings of the National Academy of Sciences of the United States of America · 2014
    Article
  20. What is a representative brain? Neuroscience meets population science.Proceedings of the National Academy of Sciences of the United States of America · 2013
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Colter MitchellColter Mitchell is with the Survey Research Center and Population Studies Center, University of Michigan, Ann Arbor, MI. Sara McLanahan is with the Department of Sociology and Woodrow Wilson School of Public and International Affairs, Princeton University, Princeton, NJ. Jeanne Brooks-Gunn is with the Teachers College and the College of Physicians and Surgeons, Columbia University, New York, NY. Irwin Garfinkel is with the School of Social Work, Columbia University. John Hobcraft is with the Department of Social Policy and Social Work, University of York, York, UK. Daniel Notterman is with the Department of Molecular Biology, Princeton University and Penn State College of Medicine, Pennsylvania State University, Hershey.
Sara McLanahan
Jeanne Brooks-Gunn
Irwin Garfinkel
John Hobcraft
Daniel Notterman

Funding

Fragile Families and the Transition to AdulthoodR01HD036916 · NICHD · PRINCETON UNIVERSITY · PI Kathryn Edin, Jane Waldfogel · 1999 to 2026
$46.3M
Reciprocal Genetic-Environmental Interactions During Childhood and AdolescenceR01HD076592 · NICHD · PRINCETON UNIVERSITY · PI NOTTERMAN, DANIEL A. · 2013 to 2023
$6.8M
ECONOMIC STATUS, PUBLIC POLICY, AND CHILD NEGLECTR01HD039135 · NICHD · PRINCETON UNIVERSITY · PI PAXSON, CHRISTINA H · 2000 to 2004
$3.1M
Child Care and Parental Employment in Fragile FamiliesR01HD040421 · NICHD · COLUMBIA UNIVERSITY TEACHERS COLLEGE · PI BROOKS-GUNN, JEANNE · 2002 to 2006
$2.8M
Columbia Population Research CenterR24HD058486 · NICHD · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI GARFINKEL, IRWIN · 2009 to 2013
$1.1M
NICHD NIH HHS R01 HD036916NICHD NIH HHS R01 HD039135NICHD NIH HHS R01 HD040421NICHD NIH HHS R01 HD076592NICHD NIH HHS R01HD36916NICHD NIH HHS R01HD39135NICHD NIH HHS R01HD40421NICHD NIH HHS R24 HD058486
6 · The paper itself

Abstract

Researchers have proposed a genetic differential sensitivity to social environmental (GDSE) model positing that individuals with certain genetic makeups are more sensitive to favorable and unfavorable environmental influences than those without these genetic makeups. We discuss several issues facing researchers who want to use GDSE to examine health: (1) the need for greater theorizing about the social environment to properly understand the size and direction of environmental influences; (2) the potential for combining multiple genetic markers to measure an individual's genetic sensitivity to environmental influence; (3) how this model and exogenous shocks deal with gene-environment correlations; (4) implications of this model for public health and prevention; and (5) how life course and developmental theories may be used to inform GDSE research.

Indexed as

Gene-Environment InteractionGenetic MarkersGenetic Predisposition to DiseaseSocial EnvironmentGenetic ResearchHumansModels, BiologicalPrimary PreventionGenetic Markers

Identifiers

PMID23927507
PMCPMC4012542

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.