ArticleAmerican journal of public health2013
How genes and the social environment moderate each other.
Article in American journal of public health, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.
- Underlying Mechanisms of Gene-Environment Interactions in Externalizing Behavior: A Systematic Review and Search for Theoretical Mechanisms.Clinical child and family psychology review · 2015Pooled it
- IGEMS: The Consortium on Interplay of Genes and Environment Across Multiple Studies - An Update.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2019Trial
- Children's psychological traits and educational performance: How schools and residential areas moderate how individual traits translate into academic outcomes.JCPP advances · 2026Article
- The long reach of childhood income inequality: a multinational twin study of gene-environment interplay on adult depressive symptoms.Psychological medicine · 2026Article
- Moderating effects of educational inequality on education polygenic scores, attained education and dementia-risk relationships.SSM - population health · 2026Article
- Maternal Social Phobia, but not Generalized Anxiety, Symptoms Interact with Early Childhood Error-Related Negativity to Prospectively Predict Child Anxiety Symptoms.Research on child and adolescent psychopathology · 2025Article
- Association of alpha-actinin-3 genotype with muscle mass and physical function in community-dwelling older adults.European geriatric medicine · 2025Article
- TRACE: applying AI language models to extract ancestry information from curated biomedical literature.Frontiers in digital health · 2025Article
- The missing hallmark of health: psychosocial adaptation.Cell stress · 2024Article
- Challenges in studying the interplay of genes and environment. A study of childhood financial distress moderating genetic predisposition for peak smoking.Journal Of Economic Psychology · 2023Article
- Implementing Core Genes and an Omnigenic Model for Behaviour Traits Prediction in Genomics.Genes · 2023Review
- Genetic Risk, Neighborhood Characteristics, and Behavioral Difficulties Among African American Adolescents Living in Very Low-Income Neighborhoods.Research on child and adolescent psychopathology · 2023Article
- Associations between error-related negativity and childhood anxiety risk differ based on socioeconomic status.Developmental psychology · 2023Article
- An investigation into DNA methylation patterns associated with risk preference in older individuals.Epigenetics · 2022Article
- Using an adoption design to test genetically based differences in risk for child behavior problems in response to home environmental influences.Development and psychopathology · 2021Article
- The Intergenerational Transmission of Early Educational Advantages: New Results Based on an Adoption Design.Research in social stratification and mobility · 2020Article
- Heritability for stroke: Essential for taking family history.Caspian journal of internal medicine · 2020Review
- The Early Growth and Development Study: A Dual-Family Adoption Study from Birth Through Adolescence.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2019Article
- Utilising Genetically-Informed Research Designs to Better Understand Family Processes and Child Development: Implications for Adoption and Foster Care Focused Interventions.Adoption & fostering · 2019Article
- Parenting and prenatal risk as moderators of genetic influences on conduct problems during middle childhood.Developmental psychology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Recent research has suggested that the social environment can moderate the expression of genetic influences on health and that genetic influences can shape an individual's sensitivity to the social environment. Evidence supports 4 major mechanisms: genes can influence an individual's response to environmental stress, genes may enhance an individual's sensitivity to both favorable and adverse environments, inherited characteristics may better fit with some environments than with others, and inherited capabilities may only become manifest in challenging or responsive environments. Further progress depends on better recognition of patterns of gene-environment interaction, improved methods of assessing the environment and its impact on genetic mechanisms, the use of appropriately designed laboratory studies, identification of heritable differences in an individual before environmental moderation occurs, and clarification of the timing of the impact of social and genetic moderation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.