ArticleVirology journal2013
The mouse and ferret models for studying the novel avian-origin human influenza A (H7N9) virus.
Article in Virology journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Virus-induced pathogenesis, vaccine development, and diagnosis of novel H7N9 avian influenza A virus in humans: a systemic literature review.The Journal of international medical research · 2020Pooled it
- Protective efficacy of a novel recombinant influenza virus carrying partial human metapneumovirus F protein epitopes.Virulence · 2024Article
- Influenza H7N9 virus disrupts the monolayer human brain microvascular endothelial cells barrier in vitro.Virology journal · 2023Article
- Review
- Correction to: The mouse and ferret models for studying the novel avian-origin human influenza A (H7N9) virus.Virology journal · 2020Article
- Article
- Article
- Clinical Correlations of Transcriptional Profile in Patients Infected With Avian Influenza H7N9 Virus.The Journal of infectious diseases · 2018Article
- Development of in vitro and in vivo neutralization assays based on the pseudotyped H7N9 virus.Scientific reports · 2018Article
- A pilot study on primary cultures of human respiratory tract epithelial cells to predict patients' responses to H7N9 infection.Oncotarget · 2018Article
- Syrian Hamster as an Animal Model for the Study of Human Influenza Virus Infection.Journal of virology · 2018Article
- Type I interferon receptor knockout mice as models for infection of highly pathogenic viruses with outbreak potential.Zoological research · 2018Article
- Ferrets that help fight the flu.Lab animal · 2016Article
- Two Genetically Similar H9N2 Influenza A Viruses Show Different Pathogenicity in Mice.Frontiers in microbiology · 2016Article
- Respiratory nanoparticle-based vaccines and challenges associated with animal models and translation.Journal of controlled release : official journal of the Controlled Release Society · 2015Review
- Suboptimal Humoral Immune Response against Influenza A(H7N9) Virus Is Related to Its Internal Genes.Clinical and vaccine immunology : CVI · 2015Article
- Human monoclonal antibodies targeting the haemagglutinin glycoprotein can neutralize H7N9 influenza virus.Nature communications · 2015Article
- IL-33 promotes ST2-dependent lung fibrosis by the induction of alternatively activated macrophages and innate lymphoid cells in mice.The Journal of allergy and clinical immunology · 2014Article
- Animal models for influenza viruses: implications for universal vaccine development.Pathogens (Basel, Switzerland) · 2014Review
- Glycomic characterization of respiratory tract tissues of ferrets: implications for its use in influenza virus infection studies.The Journal of biological chemistry · 2014Article
Corrections and comments
- Erratum issued
Authors and funding
20 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe current study was conducted to establish animal models (including mouse and ferret) for the novel avian-origin H7N9 influenza virus.
findingsA/Anhui/1/2013 (H7N9) virus was administered by intranasal instillation to groups of mice and ferrets, and animals developed typical clinical signs including body weight loss (mice and ferrets), ruffled fur (mice), sneezing (ferrets), and death (mice). Peak virus shedding from respiratory tract was observed on 2 days post inoculation (d.p.i.) for mice and 3-5 d.p.i. for ferrets. Virus could also be detected in brain, liver, spleen, kidney, and intestine from inoculated mice, and in heart, liver, and olfactory bulb from inoculated ferrets. The inoculation of H7N9 could elicit seroconversion titers up to 1280 in ferrets and 160 in mice. Leukopenia, significantly reduced lymphocytes but increased neutrophils were also observed in mouse and ferret models.
conclusionsThe mouse and ferret model enables detailed studies of the pathogenesis of this illness and lay the foundation for drug or vaccine evaluation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.