Evidence map›Paper›PMID 23927296›Full record

ReviewMedical physics2013

MR-guided focused ultrasound surgery, present and future.

David Schlesinger, Stanley Benedict, Chris Diederich, Wladyslaw Gedroyc, Alexander Klibanov, James Larner

Registry-linked trialOpen access · hybridAbstract readReview
In one paragraph

Review in Medical physics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04250376 (The Use of Transcranial Focused Ultrasound for the Treatment of Neurodegenerative Dementias), which is not on this map. Cited by 57 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 1 pooled it
9.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04250376 naunknown statusnot on this mapstarted 2017, after this paper: background citation

The Use of Transcranial Focused Ultrasound for the Treatment of Neurodegenerative Dementias

TypeinterventionalSponsorNeurological Associates of West Los AngelesRan2017 to 2025Enrolled100ConditionsMild Cognitive Impairment, Mild Dementia, Parkinson Disease, Alzheimer DiseaseArmsFocused Transcranial Ultrasound
3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 1 synthesis or guideline pooled it, 122 citations in OpenAlex.

  1. Bibliometric analysis of high-intensity focused ultrasound.Frontiers in research metrics and analytics · 2026
    Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Recent advances in transducers for through-tissue ultrasonic power transfer.Progress in biomedical engineering (Bristol, England) · 2026
    Review
  6. Review
  7. Review
  8. Tissue Ablation: Applications and Perspectives.Advanced materials (Deerfield Beach, Fla.) · 2024
    Review
  9. Review
  10. Volumetric hyperthermia delivery using the ExAblate Body MR-guided focused ultrasound system.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2024
    Article
  11. Surgical Management of Brain Tumors with Focused Ultrasound.Current oncology (Toronto, Ont.) · 2023
    Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. MRI classification using semantic random forest with auto-context model.Quantitative imaging in medicine and surgery · 2021
    Article
  18. Review
  19. Time-Resolved Passive Cavitation Mapping Using the Transient Angular Spectrum Approach.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

David SchlesingerDepartment of Radiation Oncology, University of Virginia, Charlottesville, Virginia 22908, USA. djs9c@virginia.edu
Stanley Benedict
Chris Diederich
Wladyslaw Gedroyc
Alexander Klibanov
James Larner
University of Virginia · USImperial College London · GBUniversity of California, Davis · USUniversity of California, San Francisco · US

Funding

Image-guided Ultrasound-triggered Tumor TherapyR33CA102880 · NCI · UNIVERSITY OF VIRGINIA · PI KLIBANOV, ALEXANDER L · 2008 to 2011
$1.1M
Image-guided Ultrasound-triggered Tumor TherapyR21CA102880 · NCI · UNIVERSITY OF VIRGINIA · PI KLIBANOV, ALEXANDER L · 2007 to 2007
$205k
NCI NIH HHS CA102880NCI NIH HHS R21 CA102880NCI NIH HHS R33 CA102880
6 · The paper itself

Abstract

MR-guided focused ultrasound surgery (MRgFUS) is a quickly developing technology with potential applications across a spectrum of indications traditionally within the domain of radiation oncology. Especially for applications where focal treatment is the preferred technique (for example, radiosurgery), MRgFUS has the potential to be a disruptive technology that could shift traditional patterns of care. While currently cleared in the United States for the noninvasive treatment of uterine fibroids and bone metastases, a wide range of clinical trials are currently underway, and the number of publications describing advances in MRgFUS is increasing. However, for MRgFUS to make the transition from a research curiosity to a clinical standard of care, a variety of challenges, technical, financial, clinical, and practical, must be overcome. This installment of the Vision 20∕20 series examines the current status of MRgFUS, focusing on the hurdles the technology faces before it can cross over from a research technique to a standard fixture in the clinic. It then reviews current and near-term technical developments which may overcome these hurdles and allow MRgFUS to break through into clinical practice.

Indexed as

Magnetic Resonance ImagingAnimalsEngineeringHumansSurgery, Computer-AssistedUltrasonic Surgical Procedures

Identifiers

PMID23927296
PMCPMC3724793
OpenAlexW2077082767

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.