ArticleThe Journal of the Acoustical Society of America2013
Time-reversal acoustics and ultrasound-assisted convection-enhanced drug delivery to the brain.
Article in The Journal of the Acoustical Society of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Article
- Evaluation of advective solute infiltration into porous media by pulsed focused ultrasound-induced acoustic streaming effects.Ultrasonography (Seoul, Korea) · 2024Article
- Numerical and experimental evaluation of ultrasound-assisted convection enhanced delivery to transfer drugs into brain tumors.Scientific reports · 2022Article
- High Incidence of Intracerebral Hemorrhaging Associated with the Application of Low-Intensity Focused Ultrasound Following Acute Cerebrovascular Injury by Intracortical Injection.Pharmaceutics · 2022Article
- Enhancement of cerebrospinal fluid tracer movement by the application of pulsed transcranial focused ultrasound.Scientific reports · 2022Article
- Theory for acoustic streaming in soft porous matter and its applications to ultrasound-enhanced convective delivery.Journal of therapeutic ultrasound · 2018Article
- MR-guided transcranial focused ultrasound safely enhances interstitial dispersion of large polymeric nanoparticles in the living brain.PloS one · 2018Article
- Direct brain infusion can be enhanced with focused ultrasound and microbubbles.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
- Focused Ultrasound Immunotherapy for Central Nervous System Pathologies: Challenges and Opportunities.Theranostics · 2017Review
- Emerging Applications of Therapeutic Ultrasound in Neuro-oncology: Moving Beyond Tumor Ablation.Neurosurgery · 2016Review
- Pulsed ultrasound expands the extracellular and perivascular spaces of the brain.Brain research · 2016Article
- Distribution of polymer nanoparticles by convection-enhanced delivery to brain tumors.Journal of controlled release : official journal of the Controlled Release Society · 2016Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Time-reversal acoustics is an effective way of focusing ultrasound deep inside heterogeneous media such as biological tissues. Convection-enhanced delivery is a method of delivering drugs into the brain by infusing them directly into the brain interstitium. These two technologies are combined in a focusing system that uses a "smart needle" to simultaneously infuse fluid into the brain and provide the necessary feedback for focusing ultrasound using time-reversal acoustics. The effects of time-reversal acoustics-focused ultrasound on the spatial distribution of infused low- and high-molecular weight tracer molecules are examined in live, anesthetized rats. Results show that exposing the rat brain to focused ultrasound significantly increases the penetration of infused compounds into the brain. The addition of stabilized microbubbles enhances the effect of ultrasound exposure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.