ArticleVeterinary research2013
Exploring the abomasal lymph node transcriptome for genes associated with resistance to the sheep nematode Teladorsagia circumcincta.
Article in Veterinary research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Sheep Genetic Resistance to Gastrointestinal Nematode Infections: Current Insights from Transcriptomics and Other OMICs Technologies-A Review.Pathogens (Basel, Switzerland) · 2026Review
- Comparison of Th-2 Cytokines and Associated Gene Expression in Peripheral Blood of Resistant and Susceptible Garole Sheep Infected WithJournal of parasitology research · 2026Article
- Epidemiological landscape and genetic prospects for marker-assisted selection in Kazakh sheep.Frontiers in veterinary science · 2025Review
- Successful Treatment of Eosinophilic Pustular Folliculitis with Secondary Follicular Mucin Deposition Using Indomethacin: An Atypical Case and Literature Review.Clinical, cosmetic and investigational dermatology · 2025Article
- Tannin alleviated reproductive dysfunction in pregnant ewes infected withFrontiers in veterinary science · 2025Article
- Regulatory effect of Balanites aegyptiaca ethanol extract on oxidant/antioxidant status, inflammatory cytokines, and cell apoptosis gene expression in goat abomasum experimentally infected with Haemonchus Contortus.Tropical animal health and production · 2024Article
- Article
- Mucosal Immunity of Major Gastrointestinal Nematode Infections in Small Ruminants Can Be Harnessed to Develop New Prevention Strategies.International journal of molecular sciences · 2024Review
- Functionally distinct T-helper cell phenotypes predict resistance to different types of parasites in a wild mammal.Scientific reports · 2022Article
- Investigating the development of diarrhoea through gene expression analysis in sheep genetically resistant to gastrointestinal helminth infection.Scientific reports · 2022Article
- Association analysis and functional annotation of imputed sequence data within genomic regions influencing resistance to gastro-intestinal parasites detected by an LDLA approach in a nucleus flock of Sarda dairy sheep.Genetics, selection, evolution : GSE · 2022Article
- Early Transcriptome Differences Between Pre-Infected and Naïve Kid Goats Infected WithFrontiers in veterinary science · 2022Article
- Genomic scans for selective sweeps through haplotype homozygosity and allelic fixation in 14 indigenous sheep breeds from Middle East and South Asia.Scientific reports · 2021Article
- Free Fatty Acid Receptors 2 and 3 as Microbial Metabolite Sensors to Shape Host Health: Pharmacophysiological View.Biomedicines · 2020Review
- Infection with the sheep gastrointestinal nematode Teladorsagia circumcincta increases luminal pathobionts.Microbiome · 2020Article
- Dynamic transcriptomic changes of goat abomasal mucosa in response to Haemonchus contortus infection.Veterinary research · 2020Article
- Resistance to Haemonchus contortus in Corriedale sheep is associated to high parasite-specific IgA titer and a systemic Th2 immune response.Scientific reports · 2019Article
- Differences in immune responses to Haemonchus contortus infection in the susceptible Ile de France and the resistant Santa Ines sheep under different anthelmintic treatments regimens.Veterinary research · 2019Article
- Signatures of selection for resistance to Haemonchus contortus in sheep and goats.BMC genomics · 2019Article
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
This study exploited Blackface lambs that varied in their resistance to the abomasal nematode parasite, Teladorsagia circumcincta. Infection of these lambs over 3 months identified susceptible (high adult worm count, high faecal egg count and low IgA antibody) and resistant animals that had excluded all parasites. Previous work had shown that susceptibility and resistance is dependent on the differential immune response to the parasite, which occurs within the abomasal (gastric) lymph node (ALN) that drains the site of infection. The Affymetrix ovine gene array was used to interrogate the transcriptome of the ALN to identify genes and physiological pathways associated with resistance. We used a bovine RT-qPCR array of 84 genes to validate the gene array, and also report digital gene expression analysis on the same tissues, reanalysed using the Oar v3.1 sheep genome assembly. These analyses identified Humoral Immune Response, Protein Synthesis, Inflammatory Response and Hematological System Development and Function as the two top-ranked networks associated with resistance. Central genes within these networks were IL4, IL5, IL13RA2 and in particular IL13, which confirmed that differential activation of Th2 polarized responses is critical to the resistance phenotype. Furthermore, in resistant sheep there was up-regulation of genes linked to control and suppression of inflammation. The identity of differentially-expressed chemokines and receptors in the resistant and susceptible sheep also begins to explain the cellular nature of the host response to infection. This work will greatly help in the identification of candidate genes as potential selectable markers of genetic resistance.
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