Evidence map›Paper›PMID 23926602›Full record

ArticleThe Journal of clinical investigation2013

Prenatal sensitization of a postnatal trigger for metabolic disease.

Susan K Murphy

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical investigation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Susan K MurphyDepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, Duke University Medical Center, Durham, North Carolina 27708, USA. susan.murphy@duke.edu
Duke Medical Center · US

Funding

Nutrition, Deregulation of Imprinted GenesR01ES016772 · NIEHS · DUKE UNIVERSITY · PI HOYO, CATHRINE · 2009 to 2013
$3.1M
Obesity and deregulation of imprinted genes in early lifeR01DK085173 · NIDDK · DUKE UNIVERSITY · PI HOYO, CATHRINE, MURPHY, SUSAN KAY · 2010 to 2013
$2.3M
Characterizing Alcohol's Effects on Repair of Liver InjuryRC2AA019399 · NIAAA · DUKE UNIVERSITY · PI DIEHL, ANNA MAE ELIZABETH · 2009 to 2010
$2.0M
NIAAA NIH HHS AA019399NIAAA NIH HHS RC2 AA019399NIDDK NIH HHS DK085173NIDDK NIH HHS R01 DK085173NIEHS NIH HHS ES016772NIEHS NIH HHS R01 ES016772
6 · The paper itself

Abstract

Intrahepatic cholestasis of pregnancy (ICP), marked by elevated maternal serum bile acid levels, occurs in late pregnancy and is often associated with poor perinatal outcomes. In this issue of the JCI, Papacleovoulou et al. analyze the long-term consequences of ICP and find that teens born to mothers with ICP exhibit enhanced characteristics of metabolic syndrome relative to controls. The authors also used a new ICP mouse model to support and extend these findings, demonstrating that in utero exposure to bile acids induces persistent epigenetic alterations and abnormal placental lipogenesis,setting the stage for later metabolic dysfunction.

Indexed as

AnimalsCholestasis, IntrahepaticFatty LiverFemaleHumansMaleObesityPregnancyPregnancy ComplicationsPrenatal Exposure Delayed Effects

Identifiers

PMID23926602
PMCPMC3696571
OpenAlexW2149288919

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.