ArticleJournal of reproduction & infertility2011
Frequency of antisperm antibodies in infertile women.
Article in Journal of reproduction & infertility, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Zinc levels in seminal plasma and their correlation with male infertility: A systematic review and meta-analysis.Scientific reports · 2016Pooled it
- Unexplained infertility's determinants, correlation with bacterial vaginosis and anti-sperm antibodies among Congolese women: a case‒control study.BMC women's health · 2025Article
- Antigenic homology between mouse spermatozoa and Vibrio cholerae: in-silico, in-vitro, and in-vivo evidence for immune-mediated infertility.Archives of microbiology · 2025Article
- Hijacking Sexual Immuno-Privilege in GBM-An Immuno-Evasion Strategy.International journal of molecular sciences · 2021Article
- Staphylococcusaureus protein A as a means of assessing sperm penetrability in cervical mucus in vitro.Clinical and experimental reproductive medicine · 2020Article
- Sperm success and immunity.Current topics in developmental biology · 2019Review
- Immune Infertility Should Be Positively Diagnosed Using an Accurate Method by Monitoring the Level of Anti-ACTL7a Antibody.Scientific reports · 2016Article
- Exosomes in human semen carry a distinctive repertoire of small non-coding RNAs with potential regulatory functions.Nucleic acids research · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInfertility is one of the common problems seen in couples of reproductive age. Presence of antisperm antibodies in semen and serum are amongst the causes of immunoinfertility. This study was performed to determine antisperm antibodies in cervicovaginal secretions and serum of infertile women and also measure serum levels of immunoglobulins (IgG, IgM and IgA).
methodsThe study consisted of 45 infertile women consulting the Kammal El-Sammrari Hospital for infertility from 2008 to 2009 and the control group consisted of 30 fertile women. Serum levels of immunoglobulins (IgG, IgA and IgM) were measured in the participants using single radial immune diffusion. Antisperm antibodies (ASAs) were detected in the serum of both infertile and control groups using indirect immune fluorescence test. ASAs were also detected in cervicovaginal secretion using direct sperm agglutination test in both infertile and control groups.
resultsAntisperm antibodies were found in the cervicovaginal secretions (62.2%) and sera (64.4%) of infertile women which were significantly higher (p <0.001) than those of the control group (3.3% and 3.3% respectively). There was a significant increase (p <0.001) in serum levels of IgG and IgA of infertile women (16.2 and 3.25 g/L respectively) compared with the healthy control group (7 and 1.2 g/L).
conclusionHumoral immune response and antisperm antibodies may contribute to reproductive failure in couples of reproductive age.
Indexed as
Identifiers
23926512PMC3719312W2106572350What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.