Evidence map›Paper›PMID 23926337›Full record

ArticleJournal of virology2013

Transient compartmentalization of simian immunodeficiency virus variants in the breast milk of african green monkeys.

Carrie Ho, Steven Wu, Joshua D Amos, Lisa Colvin, Shannon D Smith, Andrew B Wilks, C Todd Demarco, Christie Brinkley, Thomas N Denny, Joern E Schmitz and 2 more

Abstract read
In one paragraph

Article in Journal of virology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Carrie HoHuman Vaccine Institute.
Steven Wu
Joshua D Amos
Lisa Colvin
Shannon D Smith
Andrew B Wilks
C Todd Demarco
Christie Brinkley
Thomas N Denny
Joern E Schmitz
Allen G Rodrigo
Sallie R Permar

Funding

Viral Sequencing CoreU19AI067854 · NIAID · DUKE UNIVERSITY · PI HAYNES, BARTON F. · 2006 to 2011
$290.5M
Virus biology scientific research support componentUM1AI100645 · NIAID · DUKE UNIVERSITY · PI MCMICHAEL, ANDREW JAMES · 2012 to 2018
$204.7M
Social and Behavioral Sciences CoreP30AI064518 · NIAID · DUKE UNIVERSITY · PI Nwora Lance Okeke · 2005 to 2026
$50.5M
Immune control of SIVagm replication in vivoR01AI065335 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SCHMITZ, JOERN E. · 2006 to 2009
$2.9M
SIV-specific Immunity in breast milk during infection and after vaccinationK08AI087992 · NIAID · DUKE UNIVERSITY · PI PERMAR, SALLIE R. · 2009 to 2013
$568k
Antibody protection against SIV transmissionR21AI100760 · NIAID · DUKE UNIVERSITY · PI PERMAR, SALLIE R. · 2012 to 2013
$432k
NIAID NIH HHS K08 AI087992NIAID NIH HHS K08AI087992NIAID NIH HHS P30 AI064518NIAID NIH HHS R01 AI065335NIAID NIH HHS R21 AI100760NIAID NIH HHS R21AI100760NIAID NIH HHS U19 AI067854NIAID NIH HHS UM1 AI100645
6 · The paper itself

Abstract

Natural hosts of simian immunodeficiency virus (SIV), African green monkeys (AGMs), rarely transmit SIV via breast-feeding. In order to examine the genetic diversity of breast milk SIV variants in this limited-transmission setting, we performed phylogenetic analysis on envelope sequences of milk and plasma SIV variants of AGMs. Low-diversity milk virus populations were compartmentalized from that in plasma. However, this compartmentalization was transient, as the milk virus lineages did not persist longitudinally.

Indexed as

Genetic VariationAnimalsChlorocebus aethiopsCluster AnalysisFemaleGene Products, envMilk, HumanPhylogenyPlasmaSequence Analysis, DNASimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusGene Products, env

Identifiers

PMID23926337
PMCPMC3807282

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.