ArticleThe Journal of experimental biology2013
Beating oxygen: chronic anoxia exposure reduces mitochondrial F1FO-ATPase activity in turtle (Trachemys scripta) heart.
Article in The Journal of experimental biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 69 citations in OpenAlex.
- Mitochondrial responses to anoxia-reoxygenation exposure in crucian carp (Carassius carassius).The Journal of experimental biology · 2026Article
- Hypoxia tolerance of intertidal triplefin fish is associated with low critical oxygen tension and high phosphorylating capacity in brain mitochondria.Scientific reports · 2026Article
- Torpid 13-lined ground squirrel liver mitochondria resist anoxia-reoxygenation despite high levels of protein damage.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2023Article
- Low production of mitochondrial reactive oxygen species after anoxia and reoxygenation in turtle hearts.The Journal of experimental biology · 2023Article
- Surviving without oxygen involves major tissue specific changes in the proteome of crucian carp (PeerJ · 2023Article
- New insights into survival strategies to oxygen deprivation in anoxia-tolerant vertebrates.Acta physiologica (Oxford, England) · 2022Review
- Lactate inhibits naked mole-rat cardiac mitochondrial respiration.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2022Article
- Hypoxia tolerance in two amazon cichlids: mitochondrial respiration and cellular metabolism adjustments are result of species environmental preferences and distribution.Fish physiology and biochemistry · 2021Article
- The Long-Term Effects of Developmental Hypoxia on Cardiac Mitochondrial Function in Snapping Turtles.Frontiers in physiology · 2021Article
- Effect of hypothermia on the functional activity of liver mitochondria of grass snake (Natrix natrix): inhibition of succinate-fueled respiration and KJournal of bioenergetics and biomembranes · 2019Article
- Mitochondrial matrix pH acidifies during anoxia and is maintained by the FFEBS open bio · 2019Article
- Metabolic adaptations during extreme anoxia in the turtle heart and their implications for ischemia-reperfusion injury.Scientific reports · 2019Article
- Cardiac mitochondrial metabolism may contribute to differences in thermal tolerance of red- and white-blooded Antarctic notothenioid fishes.The Journal of experimental biology · 2018Article
- Suppression of reactive oxygen species generation in heart mitochondria from anoxic turtles: the role of complex IThe Journal of experimental biology · 2018Article
- Effects of cold on murine brain mitochondrial function.PloS one · 2018Article
- Intraspecific variation and plasticity in mitochondrial oxygen binding affinity as a response to environmental temperature.Scientific reports · 2017Article
- Adaptive Patterns of Mitogenome Evolution Are Associated with the Loss of Shell Scutes in Turtles.Molecular biology and evolution · 2017Article
- Developmental plasticity of mitochondrial function in American alligators, Alligator mississippiensis.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
- Comparative insights into mitochondrial adaptations to anoxia in brain.Neural regeneration research · 2016Article
- Mitochondrial responses to prolonged anoxia in brain of red-eared slider turtles.Biology letters · 2016Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
The freshwater turtle Trachemys scripta can survive in the complete absence of O2 (anoxia) for periods lasting several months. In mammals, anoxia leads to mitochondrial dysfunction, which culminates in cellular necrosis and apoptosis. Despite the obvious clinical benefits of understanding anoxia tolerance, little is known about the effects of chronic oxygen deprivation on the function of turtle mitochondria. In this study, we compared mitochondrial function in hearts of T. scripta exposed to either normoxia or 2 weeks of complete anoxia at 5°C and during simulated acute anoxia/reoxygenation. Mitochondrial respiration, electron transport chain activities, enzyme activities, proton conductance and membrane potential were measured in permeabilised cardiac fibres and isolated mitochondria. Two weeks of anoxia exposure at 5°C resulted in an increase in lactate, and decreases in ATP, glycogen, pH and phosphocreatine in the heart. Mitochondrial proton conductance and membrane potential were similar between experimental groups, while aerobic capacity was dramatically reduced. The reduced aerobic capacity was the result of a severe downregulation of the F1FO-ATPase (Complex V), which we assessed as a decrease in enzyme activity. Furthermore, in stark contrast to mammalian paradigms, isolated turtle heart mitochondria endured 20 min of anoxia followed by reoxygenation without any impact on subsequent ADP-stimulated O2 consumption (State III respiration) or State IV respiration. Results from this study demonstrate that turtle mitochondria remodel in response to chronic anoxia exposure and a reduction in Complex V activity is a fundamental component of mitochondrial and cellular anoxia survival.
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