ArticleBiology of reproduction2013
Translational activation of developmental messenger RNAs during neonatal mouse testis development.
Article in Biology of reproduction, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Modeling mammalian spermatogonial differentiation and meiotic initiation in vitro.Development (Cambridge, England) · 2022Article
- Differential RA responsiveness directs formation of functionally distinct spermatogonial populations at the initiation of spermatogenesis in the mouse.Development (Cambridge, England) · 2019Article
- The mTORC1 component RPTOR is required for maintenance of the foundational spermatogonial stem cell pool in mice†.Biology of reproduction · 2019Article
- Leydig cell genes change their expression and association with polysomes in a stage-specific manner in the adult mouse testis.Biology of reproduction · 2018Article
- Rhox13 is required for a quantitatively normal first wave of spermatogenesis in mice.Reproduction (Cambridge, England) · 2016Article
- Expression, sorting, and segregation of Golgi proteins during germ cell differentiation in the testis.Molecular biology of the cell · 2015Article
- Mammalian target of rapamycin complex 1 (mTORC1) Is required for mouse spermatogonial differentiation in vivo.Developmental biology · 2015Article
- Compartmentalization of membrane trafficking, glucose transport, glycolysis, actin, tubulin and the proteasome in the cytoplasmic droplet/Hermes body of epididymal sperm.Open biology · 2015Article
- Transcriptional and translational heterogeneity among neonatal mouse spermatogonia.Biology of reproduction · 2015Article
- Retinoic acid regulates Kit translation during spermatogonial differentiation in the mouse.Developmental biology · 2015Article
- Riding the spermatogenic wave: profiling gene expression within neonatal germ and sertoli cells during a synchronized initial wave of spermatogenesis in mice.Biology of reproduction · 2014Article
- Retinoic acid induces multiple hallmarks of the prospermatogonia-to-spermatogonia transition in the neonatal mouse.Biology of reproduction · 2014Article
- Roles of RNA-binding Proteins and Post-transcriptional Regulation in Driving Male Germ Cell Development in the Mouse.Advances in experimental medicine and biologyArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The basic tenets of germ cell development are conserved among metazoans. Following lineage commitment in the embryo, germ cells proliferate, transition into meiosis, and then differentiate into gametes capable of fertilization. In lower organisms such as Drosophila and C. elegans, germline stem cells make the decision to proliferate or enter meiosis based in large part on the regulated expression of genes by translational control. This study undertakes a direct characterization of mRNAs that experience translational control and their involvement in similar decisions in the mammalian testis. We previously showed that translation of mRNA encoding the germ cell-specific gene Rhox13 was suppressed in the fetal and neonatal testis. By investigating changes in message utilization during neonatal testis development, we found that a large number of mRNAs encoding both housekeeping and germ cell-specific proteins experience enhanced translational efficiency, rather than increase in abundance, in the testis as quiescent gonocytes transition to mitotic spermatogonia. Our results indicate that translational control is a significant regulator of the germ cell proteome during neonatal testis development.
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