ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Rectifying electrical synapses can affect the influence of synaptic modulation on output pattern robustness.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Defining the electrical synapse.Nature reviews. Neuroscience · 2026Review
- Blue plaque review series: Thomas Graham Brown: Before his time.Experimental physiology · 2026Review
- Neuromodulators Generate Multiple Context-Relevant Behaviors in Recurrent Neural Networks.Neural computation · 2026Article
- Biological noise is a key determinant of the reproducibility and adaptability of cardiac pacemaking and EC coupling.The Journal of general physiology · 2022Review
- Modeling of sustained spontaneous network oscillations of a sexually dimorphic brainstem nucleus: the role of potassium equilibrium potential.Journal of computational neuroscience · 2021Article
- Neuronal Switching between Single- and Dual-Network Activity via Modulation of Intrinsic Membrane Properties.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Molecular basis of junctional current rectification at an electrical synapse.Science advances · 2020Article
- Beyond plasticity: the dynamic impact of electrical synapses on neural circuits.Nature reviews. Neuroscience · 2019Review
- Innexin expression in electrically coupled motor circuits.Neuroscience letters · 2019Review
- Article
- Xolotl: An Intuitive and Approachable Neuron and Network Simulator for Research and Teaching.Frontiers in neuroinformatics · 2018Article
- Gap junctional signaling in pattern regulation: Physiological network connectivity instructs growth and form.Developmental neurobiology · 2017Review
- Complicating connectomes: Electrical coupling creates parallel pathways and degenerate circuit mechanisms.Developmental neurobiology · 2017Review
- Functional asymmetry and plasticity of electrical synapses interconnecting neurons through a 36-state model of gap junction channel gating.PLoS computational biology · 2017Article
- Article
- Dynamical state of the network determines the efficacy of single neuron properties in shaping the network activity.Scientific reports · 2016Article
- Reverberation of excitation in neuronal networks interconnected through voltage-gated gap junction channels.The Journal of general physiology · 2016Article
- Gap Junction Blockers: An Overview of their Effects on Induced Seizures in Animal Models.Current neuropharmacology · 2016Review
- Opioids potentiate electrical transmission at mixed synapses on the Mauthner cell.Journal of neurophysiology · 2015Article
- Computational models in the age of large datasets.Current opinion in neurobiology · 2015Review
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2 authors.
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Abstract
Rectifying electrical synapses are commonplace, but surprisingly little is known about how rectification alters the dynamics of neuronal networks. In this study, we use computational models to investigate how rectifying electrical synapses change the behavior of a small neuronal network that exhibits complex rhythmic output patterns. We begin with an electrically coupled circuit of three oscillatory neurons with different starting frequencies, and subsequently add two additional neurons and inhibitory chemical synapses. The five-cell model represents a pattern-generating neuronal network with two simultaneous rhythms competing for the recruitment of a hub neuron. We compare four different configurations of rectifying synapse placement and polarity, and we investigate how rectification changes the functional output of this network. Rectification can have a striking effect on the network's sensitivity to alterations of the strengths of the chemical synapses in the network. For some configurations, the rectification makes the circuit dynamics remarkably robust against changes in synaptic strength compared with the nonrectifying case. Based on our findings, we predict that modulation of rectifying electrical synapses could have functional consequences for the neuronal circuits that express them.
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