ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
How to scale down postsynaptic strength.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Btbd11 regulates glutamatergic synapse organization in GABAergic inhibitory interneurons.bioRxiv : the preprint server for biology · 2026Article
- Altered wakeful theta activity characterizes levodopa-induced dyskinesia in Parkinson's disease.NPJ Parkinson's disease · 2026Article
- Activity Deprivation Modulates the Shank3/Homer1/mGluR5 Signaling Pathway to Enable Synaptic Upscaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- Anti-P antibodies that impair memory perturb hippocampal glutamatergic receptor trafficking, synapse structure and microglia.Molecular medicine (Cambridge, Mass.) · 2025Article
- Article
- Antiretroviral drugs from multiple classes induce loss of excitatory synapses between hippocampal neurons in culture.Frontiers in pharmacology · 2024Article
- Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity.NPJ Parkinson's disease · 2023Article
- Article
- A bidirectional switch in the Shank3 phosphorylation state biases synapses toward up- or downscaling.eLife · 2022Article
- Homeostatic scaling is driven by a translation-dependent degradation axis that recruits miRISC remodeling.PLoS biology · 2021Article
- The Role of Amyloid-Beta and Tau in the Early Pathogenesis of Alzheimer's Disease.Medical science monitor : international medical journal of experimental and clinical research · 2021Review
- The biophysical basis underlying the maintenance of early phase long-term potentiation.PLoS computational biology · 2021Article
- Cortical Seizures inInternational journal of molecular sciences · 2019Article
- Classification of Visual Cortex Plasticity Phenotypes following Treatment for Amblyopia.Neural plasticity · 2019Article
- The AMPA Receptor Code of Synaptic Plasticity.Neuron · 2018Review
- Stargazin Dephosphorylation Mediates Homeostatic Synaptic Downscaling of Excitatory Synapses.Frontiers in molecular neuroscience · 2018Article
- Shank and Zinc Mediate an AMPA Receptor Subunit Switch in Developing Neurons.Frontiers in molecular neuroscience · 2018Article
- Impaired Tuning of Neural Ensembles and the Pathophysiology of Schizophrenia: A Translational and Computational Neuroscience Perspective.Biological psychiatry · 2017Review
- In Vivo Measurement of Glycine Receptor Turnover and Synaptic Size Reveals Differences between Functional Classes of Motoneurons in Zebrafish.Current biology : CB · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Synaptic scaling is a form of synaptic plasticity that contributes to the homeostatic regulation of neuronal activity both in vitro and in vivo, by bidirectionally and proportionally adjusting postsynaptic AMPA receptor (AMPAR) abundance to compensate for chronic perturbations in activity. This proportional regulation of synaptic strength allows synaptic scaling to normalize activity without disrupting the synapse-specific differences in strength thought to underlie memory storage, but how such proportional scaling of synaptic strength is accomplished at the biophysical level is unknown. Here we addressed this question in cultured rat visual cortical pyramidal neurons. We used photoactivation and fluorescence recovery after photobleaching of fluorescently tagged AMPAR to show that scaling down, but not up, decreases the steady-state accumulation of synaptic AMPAR by increasing the rate at which they unbind from and exit the postsynaptic density (Koff). This increase in Koff was not diffusion limited, was independent of AMPAR endocytosis, and was prevented by a scaffold manipulation that specifically blocks scaling down, suggesting that it is accomplished through enhanced dissociation of AMPAR from synaptic scaffold tethers. Finally, simulations show that increasing Koff decreases synaptic strength multiplicatively, by reducing the fractional occupancy of available scaffold "slots." These data demonstrate that scaling down is accomplished through a regulated increase in Koff, which in turn reduces the fractional occupancy of synaptic scaffolds to proportionally reduce synaptic strength.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.