ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
KIBRA polymorphism is associated with individual differences in hippocampal subregions: evidence from anatomical segmentation using high-resolution MRI.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Pooled it
- The intrinsic time tracker: temporal context is embedded in entorhinal and hippocampal functional connectivity patterns.Nature communications · 2025Article
- Effects of Early Midlife Ovarian Removal on Medial Temporal Lobe Gray Matter Volume and Recognition Memory.Hippocampus · 2025Article
- Neuroanatomical changes observed over the course of a human pregnancy.Nature neuroscience · 2024Article
- The Effect of Segmentation Method on Medial Temporal Lobe Subregion Volumes in Aging.Human brain mapping · 2024Article
- Circadian Rhythms Tied to Changes in Brain Morphology in a Densely Sampled Male.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Circadian rhythms tied to changes in brain morphology in a densely-sampled male.bioRxiv : the preprint server for biology · 2024Article
- KIBRA single nucleotide polymorphism is associated with hippocampal subfield volumes and cognition across development.Brain structure & function · 2024Article
- Hippocampal subfields and their neocortical interactions during autobiographical memory.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Release of cognitive and multimodal MRI data including real-world tasks and hippocampal subfield segmentations.Scientific data · 2023Article
- Posterior hippocampal CA2/3 volume is associated with autobiographical memory recall ability in lower performing individuals.Scientific reports · 2023Article
- Deciphering the Effect of Different Genetic Variants on Hippocampal Subfield Volumes in the General Population.International journal of molecular sciences · 2023Article
- Disturbed sleep is associated with reduced verbal episodic memory and entorhinal cortex volume in younger middle-aged women with risk-reducing early ovarian removal.Frontiers in endocrinology · 2023Article
- Brain microstructural alterations in the left precuneus mediate the association between KIBRA polymorphism and working memory in healthy adults: a diffusion kurtosis imaging study.Brain imaging and behavior · 2022Article
- Genetic Influences on Hippocampal Subfields: An Emerging Area of Neuroscience Research.Neurology. Genetics · 2021Review
- The relationship between hippocampal subfield volumes and autobiographical memory persistence.Hippocampus · 2021Article
- Functional connectivity along the anterior-posterior axis of hippocampal subfields in the ageing human brain.Hippocampus · 2019Article
- Differences in functional connectivity along the anterior-posterior axis of human hippocampal subfields.NeuroImage · 2019Article
- Volumetric Changes in Hippocampal Subregions and Memory Performance in Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis.Neuroscience bulletin · 2018Article
- The role of KIBRA in reconstructive episodic memory.Molecular medicine (Cambridge, Mass.) · 2018Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
The KIBRA gene has been associated with episodic memory in several recent reports; carriers of the T-allele show enhanced episodic memory performance relative to noncarriers. Gene expression studies in human and rodent species show high levels of KIBRA in the hippocampus, particularly in the subfields. The goal of the present study was to determine whether the KIBRA C→T polymorphism is also associated with volume differences in the human hippocampus and whether specific subfields are differentially affected by KIBRA genotype. High-resolution magnetic resonance imaging (T2-weighted, voxel size=0.4×0.4 mm, in-plane) was used to manually segment hippocampal cornu ammonis (CA) subfields, dentate gyrus (DG), and the subiculum as well as adjacent medial temporal lobe cortices in healthy carriers and noncarriers of the KIBRA T-allele (rs17070145). Overall, we found that T-carriers had a larger hippocampal volume relative to noncarriers. The structural differences observed were specific to the CA fields and DG regions of the hippocampus, suggesting a potential neural mechanism for the effects of KIBRA on episodic memory performance reported previously.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.