Trial reportThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Dopamine modulates risk-taking as a function of baseline sensation-seeking trait.
Trial report in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 68 citations in OpenAlex.
- The effects of pramipexole on motivational vigour during a saccade task: a placebo-controlled study in healthy adults.Psychopharmacology · 2024Trial
- Gambling on an empty stomach: Hunger modulates preferences for learned but not described risks.Brain and behavior · 2023Trial
- When brain stimulation backfires: the effects of prefrontal cortex stimulation on impulsivity.Social cognitive and affective neuroscience · 2022Trial
- A Neurofunctional Domains Approach to Evaluate D1/D5 Dopamine Receptor Partial Agonism on Cognition and Motivation in Healthy Volunteers With Low Working Memory Capacity.The international journal of neuropsychopharmacology · 2020Trial
- Dopamine Increases a Value-Independent Gambling Propensity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Trial
- Dopamine Transporter Correlates and Occupancy by Modafinil in Cocaine-Dependent Patients: A Controlled Study With High-Resolution PET and [(11)C]-PE2I.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Trial
- A pilot study of women's affective responses to common and uncommon forms of aerobic exercise.Psychology & health · 2016Trial
- Dopaminergic Modulation of Decision Making and Subjective Well-Being.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Trial
- Serotonin-dopamine polarity and social polarization.Frontiers in psychology · 2026Article
- Neurogenetics and Epigenetics of Spirituality and Religion: Seeking Genospirituality Via the Lens of Hierarchical Neuro-Spiritual Model (HNSM).Neurology (E-Cronicon) · 2025Article
- The role of dopamine in foraging decisions in social insects.Frontiers in insect science · 2025Review
- The Association Between Causality Orientation and Internet Gaming Disorder, and the Role of Sensation Seeking, Anxiety, and Depression.Psychiatry investigation · 2024Article
- Risk-Taking Is Associated with Decreased Subjective Value Signals and Increased Prediction Error Signals in the Hot Columbia Card Task.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Sex-Specific and Traumatic Brain Injury Effects on Dopamine Receptor Expression in the Hippocampus.International journal of molecular sciences · 2023Article
- Decomposing risky decision-making in methamphetamine use disorder: Behavioral updating and D2 dopamine receptors.Drug and alcohol dependence · 2023Article
- Toward a Unifying Account of Dopamine's Role in Cost-Benefit Decision Making.Biological psychiatry global open science · 2023Review
- Effect of real-world fear on risky decision-making in medical school-based students: A quasi-experimental study.Frontiers in behavioral neuroscience · 2023Article
- Dopamine increases risky choice while D2 blockade shortens decision time.Experimental brain research · 2022Article
- Dorsolateral prefrontal cortex plays causal role in probability weighting during risky choice.Scientific reports · 2022Article
- On the learning of addictive behavior: Sensation-seeking propensity predicts dopamine turnover in dorsal striatum.Brain imaging and behavior · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Trait sensation-seeking, defined as a need for varied, complex, and intense sensations, represents a relatively underexplored hedonic drive in human behavioral neuroscience research. It is related to increased risk for a range of behaviors including substance use, gambling, and risky sexual practice. Individual differences in self-reported sensation-seeking have been linked to brain dopamine function, particularly at D2-like receptors, but so far no causal evidence exists for a role of dopamine in sensation-seeking behavior in humans. Here, we investigated the effects of the selective D2/D3 agonist cabergoline on performance of a probabilistic risky choice task in healthy humans using a sensitive within-subject, placebo-controlled design. Cabergoline significantly influenced the way participants combined different explicit signals regarding probability and loss when choosing between response options associated with uncertain outcomes. Importantly, these effects were strongly dependent on baseline sensation-seeking score. Overall, cabergoline increased sensitivity of choice to information about probability of winning; while decreasing discrimination according to magnitude of potential losses associated with different options. The largest effects of the drug were observed in participants with lower sensation-seeking scores. These findings provide evidence that risk-taking behavior in humans can be directly manipulated by a dopaminergic drug, but that the effectiveness of such a manipulation depends on baseline differences in sensation-seeking trait. This emphasizes the importance of considering individual differences when investigating manipulation of risky decision-making, and may have relevance for the development of pharmacotherapies for disorders involving excessive risk-taking in humans, such as pathological gambling.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.