Evidence map›Paper›PMID 23926212›Full record

ArticleAlcohol and alcoholism (Oxford, Oxfordshire)

A cross-sectional study of attitudes about the use of genetic testing for clinical care among patients with an alcohol use disorder.

Brittany Strobel, Lauren McManus, Shirley Leong, Frederic Blow, Valerie Slaymaker, Wade Berrettini, Adam J Gordon, Charles O'Brien, David Oslin

Open access · hybridAbstract read
In one paragraph

Article in Alcohol and alcoholism (Oxford, Oxfordshire). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Brittany StrobelCorresponding author: Perelman School of Medicine, University of Pennsylvania, 3900 Woodland Ave., Philadelphia, PA 19104, USA. oslin@upenn.edu.
Lauren McManus
Shirley Leong
Frederic Blow
Valerie Slaymaker
Wade Berrettini
Adam J Gordon
Charles O'Brien
David Oslin
University of Pennsylvania · USTreatment Research Institute · USHazelden Betty Ford Graduate School of Addiction Studies · USPhiladelphia VA Medical Center · USVA Pittsburgh Healthcare System · US

Funding

Pharmacogenetic Response to Naltrexone for Alcohol DependenceR01AA017164 · NIAAA · UNIVERSITY OF PENNSYLVANIA · PI OSLIN, DAVID W. · 2008 to 2012
$3.0M
NIAAA NIH HHS AA017164
6 · The paper itself

Abstract

aimModification and individualization of medical treatments due to genetic testing has the potential to revolutionize healthcare delivery. As evidence mounts that genetic testing may improve treatment decisions for patients with alcohol use disorder (AUD), we explored patient concerns and attitudes toward genetic testing.

methodsSubjects of two USA cross-sectional AUD studies were surveyed regarding their attitudes regarding the use of genetic testing for AUD treatment.

resultsFour hundred and fifty-seven participants were surveyed. Overall, subjects showed a high degree of willingness to provide DNA for clinical use and recognized genetics as important to the pathophysiology of a number of disorders including AUD. There were, however, significant concerns expressed related to insurance denial or employment problems.

conclusionWe found that patients enrolled in AUD studies had some concerns about use of genetic testing. The patients in these two samples were, however, willing and knowledgeable about providing DNA samples.

Indexed as

AttitudeAdultAlcoholismCross-Sectional StudiesDiagnostic and Statistical Manual of Mental DisordersDNAEmploymentFemaleGenetic TestingGenotypeHumansInsurance, HealthMaleMiddle AgedPrecision MedicineDNA

Identifiers

PMID23926212
PMCPMC3799560
OpenAlexW2154367613

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.