ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2013
Nonuniform, age-related decrements in regional sweating and skin blood flow.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 74 citations in OpenAlex.
- Exploring the mechanisms underpinning sweating: the development of a specialized ventilated capsule for use with intradermal microdialysis.Physiological reports · 2016Trial
- At what level of heat load are age-related impairments in the ability to dissipate heat evident in females?PloS one · 2015Trial
- Epidemiology, mechanisms and clinical implications of heat-related kidney disease.Nature reviews. Nephrology · 2026Review
- Sweat glands in action: the role of biological and environmental factors, exercise, and dermatologic conditions in sudomotor function.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2026Review
- Intersection of Climate and Environmental Change and Priority Health Outcomes Across the Life Course: Working Group 1 Report from the "Agriculture and Diet: Value Added for Nutrition, Translation, and Adaptation in a Global Ecology" (ADVANTAGE) Project.Advances in nutrition (Bethesda, Md.) · 2026Review
- Thermophysiological BioEnergy Index as a Biomarker of Biological Ageing: A Large-Scale Microwave Radiometry Study.Diagnostics (Basel, Switzerland) · 2026Article
- Design of Knitted Fabrics with Biomimetic Bird Feather Hierarchical Structures for Thermal and Moisture Adaptation in Outdoor Environments for the Elderly.Biomimetics (Basel, Switzerland) · 2026Article
- Cold temperatures, hot risks: perioperative hypothermia in geriatric patients - a narrative review.Anesthesia and pain medicine · 2025Review
- Effects of individual characteristics and local body functions on sweating response: A review.International journal of biometeorology · 2024Review
- Critical environmental core temperature limits and heart rate thresholds across the adult age span (PSU HEAT Project).Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Experimental research in environmentally induced hyperthermic older persons: A systematic quantitative literature review mapping the available evidence.Temperature (Austin, Tex.) · 2024Article
- A physiological approach for assessing human survivability and liveability to heat in a changing climate.Nature communications · 2023Article
- Article
- Heat stress vulnerability and critical environmental limits for older adults.Communications earth & environment · 2023Article
- Human temperature regulation under heat stress in health, disease, and injury.Physiological reviews · 2022Review
- Aging Hearts in a Hotter, More Turbulent World: The Impacts of Climate Change on the Cardiovascular Health of Older Adults.Current cardiology reports · 2022Review
- Revisiting regional variation in the age-related reduction in sweat rate during passive heat stress.Physiological reports · 2022Article
- Eccrine sweat glands' maximum ion reabsorption rates during passive heating in older adults (50-84 years).European journal of applied physiology · 2021Article
- Temperature regulation during exercise in the heat: Insights for the aging athlete.Journal of science and medicine in sport · 2021Review
- Body mapping of regional sweat distribution in young and older males.European journal of applied physiology · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Aging is associated with attenuated thermoregulatory function that varies regionally over the body. Decrements in vasodilation and sweating are well documented with age, yet limited data are available concerning the regional relation between these responses. We aimed to examine age-related alterations in the relation between regional sweating (RSR) and skin blood flow (SkBF) to thermal and pharmacological stimuli. Four microdialysis fibers were inserted in the ventral forearm, abdomen, thigh, and lower back of eight healthy aged subjects (64 ± 7 yr) and nine young (23 ± 3 yr) during 1) ACh dose response (1 × 10(-7) to 0.1 M, mean skin temperature 34°C) and 2) passive whole body heating to Δ1°C rise in oral temperature (Tor). RSR and SkBF were measured over each microdialysis membrane using ventilated capsules and laser-Doppler flowmetry. Maximal SkBF was measured at the end of both protocols (50 mM SNP). Regional sweating thresholds and RSR were attenuated in aged vs. young at all sites (P < 0.0001) during whole body heating. Vasodilation thresholds were similar between groups (P > 0.05). Attenuated SkBF were observed at the arm and back in the aged, representing 56 and 82% of those in the young at these sites, respectively (0.5 ΔTor). During ACh perfusion, SkBF (P = 0.137) and RSR were similar between groups (P = 0.326). Together these findings suggest regional age-related decrements in heat-activated sweat gland function but not cholinergic sensitivity. Functional consequences of such thermoregulatory impairment include the compromised ability of older individuals to defend core temperature during heat exposure and a subsequently greater susceptibility to heat-related illness and injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.