ArticleJournal of neurophysiology2013
Light adaptation alters the source of inhibition to the mouse retinal OFF pathway.
Article in Journal of neurophysiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Divergent molecular and circuit mechanisms underlie light entrainment of retinal and suprachiasmatic nucleus circadian clocks.Cellular and molecular life sciences : CMLS · 2026Article
- Optogenetic Isolation of the Amacrine Cell-OFF Bipolar Cell Synapse Shows Selective D1R Control of Glycinergic Transmission.bioRxiv : the preprint server for biology · 2026Article
- Cannabinoid Signaling Selectively Modulates GABAergic Inhibitory Input to OFF Bipolar Cells in Rat Retina.Investigative ophthalmology & visual science · 2020Article
- Inhibitory components of retinal bipolar cell receptive fields are differentially modulated by dopamine D1 receptors.Visual neuroscience · 2020Article
- Dopamine D1 receptor activation reduces local inner retinal inhibition to light-adapted levels.Journal of neurophysiology · 2019Article
- Selective synaptic connections in the retinal pathway for night vision.The Journal of comparative neurology · 2019Article
- Electrophysiological Studies on The Dynamics of Luminance Adaptation in the Mouse Retina.Vision (Basel, Switzerland) · 2017Article
- Contributions of Rod and Cone Pathways to Retinal Direction Selectivity Through Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Light adaptation alters inner retinal inhibition to shape OFF retinal pathway signaling.Journal of neurophysiology · 2016Article
- Low concentrations of ethanol but not of dimethyl sulfoxide (DMSO) impair reciprocal retinal signal transduction.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2015Article
- Differential encoding of spatial information among retinal on cone bipolar cells.Journal of neurophysiology · 2015Article
- NMDA and AMPA receptors contribute similarly to temporal processing in mammalian retinal ganglion cells.The Journal of physiology · 2014Article
- Wiring patterns in the mouse retina: collecting evidence across the connectome, physiology and light microscopy.The Journal of physiology · 2014Review
- Post-receptor adaptation: lighting up the details.Current biology : CB · 2014Article
- Ionotropic GABA Receptors and Distal Retinal ON and OFF Responses.Scientifica · 2014Review
- Article
Corrections and comments
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Authors and funding
2 authors.
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Abstract
Sensory systems must avoid saturation to encode a wide range of stimulus intensities. One way the retina accomplishes this is by using both dim-light-sensing rod and bright-light-sensing cone photoreceptor circuits. OFF cone bipolar cells are a key point in this process, as they receive both excitatory input from cones and inhibitory input from AII amacrine cells via the rod pathway. However, in addition to AII amacrine cell input, other inhibitory inputs from cone pathways also modulate OFF cone bipolar cell light signals. It is unknown how these inhibitory inputs to OFF cone bipolar cells change when switching between rod and cone pathways or whether all OFF cone bipolar cells receive rod pathway input. We found that one group of OFF cone bipolar cells (types 1, 2, and 4) receive rod-mediated inhibitory inputs that likely come from the rod-AII amacrine cell pathway, while another group of OFF cone bipolar cells (type 3) do not. In both cases, dark-adapted rod-dominant light responses showed a significant contribution of glycinergic inhibition, which decreased with light adaptation and was, surprisingly, compensated by an increase in GABAergic inhibition. As GABAergic input has distinct timing and spatial spread from glycinergic input, a shift from glycinergic to GABAergic inhibition could significantly alter OFF cone bipolar cell signaling to downstream OFF ganglion cells. Larger GABAergic input could reflect an adjustment of OFF bipolar cell spatial inhibition, which may be one mechanism that contributes to retinal spatial sensitivity in the light.
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