ArticleHernia : the journal of hernias and abdominal wall surgery2014
Association of collagen type I alpha 1 gene polymorphism with inguinal hernia.
Article in Hernia : the journal of hernias and abdominal wall surgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- The inheritance of groin hernias: an updated systematic review with meta-analyses.Hernia : the journal of hernias and abdominal wall surgery · 2023Pooled it
- Investigation of ELF5, KIF18A, NPTX1 and COL23A1 genes in the pathophysiology of indirect inguinal hernia in children.Pediatric surgery international · 2026Article
- ECM Remodeling in Direct Inguinal Hernia: The Role of Aging, Oxidative Stress, and Antioxidants Defenses.Clinics and practice · 2025Review
- GATA6 and TBX3 gene expressions analysis of indirect inguinal hernia sacs in children.Pediatric surgery international · 2025Article
- Sex-specific genetic variants associated with adult-onset inguinal hernia in a Taiwanese population.International journal of medical sciences · 2023Article
- "Locus minoris resistentiae" and connective tissue weakness in older women: a case report and literature review on pelvic organ prolapse with inguinal bladder hernia.BMC women's health · 2021Review
- Article
- Three-dimensional visualization and measurement of myopectineal orifice in non-inguinal hernia patients.Surgical and radiologic anatomy : SRA · 2020Article
- A network analysis revealed the essential and common downstream proteins related to inguinal hernia.PloS one · 2020Article
- Etiology of Inguinal Hernias: A Comprehensive Review.Frontiers in surgery · 2017Review
- A genome-wide association study identifies four novel susceptibility loci underlying inguinal hernia.Nature communications · 2015Article
- Genetic analysis of the TBX2 gene promoter in indirect inguinal hernia.Hernia : the journal of hernias and abdominal wall surgery · 2014Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeA positive family history is an important risk factor for inguinal hernia development, suggesting a genetic trait for hernia disease. However, gene mutations responsible for abdominal wall hernia formation in humans have not yet been studied. We aimed to evaluate whether the functional Sp1 binding site polymorphism within intron 1 of the collagen type I, alpha 1 (COL1A1) gene was associated specifically with inguinal hernia disease.
methods85 participants with surgically diagnosed inguinal hernia disease, and 82 physically active controls without any history of connective tissue disease and hernia were recruited for this case-control genetic association study. Polymerase chain reaction and restriction fragment length polymorphism and agarose gel electrophoresis techniques were used to detect these polymorphisms.
resultsSignificantly, more patients gave a positive family history for an inguinal hernia compared to healthy controls (OR 3.646, 95 % CI 1.375-9.670, P = 0.006). COL1A1 Sp1 SNP (rs 1800012) was identified. Results demostrated statistically significant deviation from HWE for cases (P = 0.007), but not for the controls (P = 0.276). Our results revealed an increased frequency of COL1A1 Sp1 Ss genotype in inguinal hernia patients (OR 3.593, 95 % CI 1.867-6.915, P = 0.000).
conclusionsThis results suggest that polymorphism of the COL1A1 Sp1 binding site is associated with an increased risk for developing inguinal hernias. So, rs 1800012 locus is a potential candidate region for susceptibility in molecular mechanism of inguinal hernia pathophysiology.
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