ReviewJournal of bone and mineral metabolism2013
Strontium ranelate: in search for the mechanism of action.
Review in Journal of bone and mineral metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Impact of anti-fracture medications on bone material and strength properties: a systematic review and meta-analysis.Frontiers in endocrinology · 2024Pooled it
- Effects of strontium ranelate on bone mass and bone turnover in women with thalassemia major-related osteoporosis.Journal of bone and mineral metabolism · 2016Trial
- SNPs in GPCR Genes and Impaired Osteogenic Potency in Osteoporotic Patient Lines-Based Study.International journal of molecular sciences · 2024Article
- Strontium Functionalization of Biomaterials for Bone Tissue Engineering Purposes: A Biological Point of View.Materials (Basel, Switzerland) · 2022Review
- The Influence of Strontium on Bone Tissue Metabolism and Its Application in Osteoporosis Treatment.International journal of molecular sciences · 2021Review
- Inorganic Agents for Enhanced Angiogenesis of Orthopedic Biomaterials.Advanced healthcare materials · 2021Review
- CaSR as a Therapeutic Target and Tool in Human Dental Pulp: A Concise Review and Novel Hypothesis.Oral health & preventive dentistry · 2020Review
- Development of local strontium ranelate delivery systems and long term in vitro drug release studies in osteogenic medium.Scientific reports · 2018Article
- Effect of Zishen Jiangtang Pill, a Chinese Herbal Product, on Rats with Diabetic Osteoporosis.Evidence-based complementary and alternative medicine : eCAM · 2018Article
- Effects of strontium ranelate treatment on osteoblasts cultivated onto scaffolds of trabeculae bovine bone.Journal of bone and mineral metabolism · 2018Article
- Effect of strontium ranelate on pain behavior in an experimental model of osteoarthritis.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2017Article
- Bone-seeking agents for the treatment of bone disorders.Drug delivery and translational research · 2017Review
- The Feasibility and Functional Performance of Ternary Borate-Filled Hydrophilic Bone Cements: Targeting Therapeutic Release Thresholds for Strontium.Journal of functional biomaterials · 2017Article
- A new contralateral atypical femoral fracture despite sequential therapy with teriparatide and strontium ranelate.Bone reports · 2017Article
- Comparison of parathyroid hormone and strontium ranelate in combination with whole-body vibration in a rat model of osteoporosis.Journal of bone and mineral metabolism · 2017Article
- The effect of strontium ranelate on the healing of a fractured ulna with bone gap in rabbit.BMC veterinary research · 2016Article
- The Stimulatory Effect of Strontium Ions on Phytoestrogens Content in Glycine max (L.) Merr.Molecules (Basel, Switzerland) · 2016Article
- Sparse feature selection methods identify unexpected global cellular response to strontium-containing materials.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Role of bone-anabolic agents in the treatment of breast cancer bone metastases.Breast cancer research : BCR · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Strontium ranelate is a medicine with evidenced effects on the risk of fractures. The heterogeneity of strontium distribution in bone, quality of bone mineral crystals in young bone packets on bone surfaces formed during strontium ranelate administration, and activation of the calcium sensing receptor may, at least partially, explain the beneficial effects of SrR on reducing the risk of fractures. In this review, the concept of the dual action of strontium ranelate is also discussed. However, sufficient evidence for the bone anabolic effect of SrR does not exist in humans. The knowledge of the mechanism of action of SrR is important not only for the explanation of the effects of SrR upon the skeleton, but also for the safety of treatment for other tissues.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.