ArticleLab on a chip2013
Electric impedance microflow cytometry for characterization of cell disease states.
Article in Lab on a chip, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed.
- Event-Preserving Neural Network Denoising for Impedance Flow Cytometry.Nanomaterials (Basel, Switzerland) · 2026Article
- The Application of Microfluidic Chips in Primary Urological Cancer: Recent Advances and Future Perspectives.Smart medicine · 2025Review
- Deformability of Heterogeneous Red Blood Cells in Aging and Related Pathologies.Aging and disease · 2024Review
- On-Chip Impedance Spectroscopy of Malaria-Infected Red Blood Cells.Sensors (Basel, Switzerland) · 2024Article
- Next generation microfluidics: fulfilling the promise of lab-on-a-chip technologies.Lab on a chip · 2024Review
- A Review on Microfluidics-Based Impedance Biosensors.Biosensors · 2023Review
- Article
- Developments of Conventional and Microfluidic Flow Cytometry Enabling High-Throughput Characterization of Single Cells.Biosensors · 2022Review
- Recent Advances in Electrical Impedance Sensing Technology for Single-Cell Analysis.Biosensors · 2021Review
- Systematic Review: Microfluidics and Plasmodium.Micromachines · 2021Review
- A portable impedance microflow cytometer for measuring cellular response to hypoxia.Biotechnology and bioengineering · 2021Article
- Biosensors for Detection of Human Placental Pathologies: A Review of Emerging Technologies and Current Trends.Translational research : the journal of laboratory and clinical medicine · 2019Review
- Use of an Insulation Layer on the Connection Tracks of a Biosensor with Coplanar Electrodes to Increase the Normalized Impedance Variation.Biosensors · 2019Article
- Electrical Impedance Characterization of Erythrocyte Response to Cyclic Hypoxia in Sickle Cell Disease.ACS sensors · 2019Article
- Influence of Electrode Connection Tracks on Biological Cell Measurements by Impedance Spectroscopy.Sensors (Basel, Switzerland) · 2019Article
- Developments in label-free microfluidic methods for single-cell analysis and sorting.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2019Review
- Dielectric characterization ofJournal of the Royal Society, Interface · 2018Article
- Multi-parametric cell profiling with a CMOS quad-modality cellular interfacing array for label-free fully automated drug screening.Lab on a chip · 2018Article
- Electrical impedance microflow cytometry with oxygen control for detection of sickle cells.Sensors and actuators. B, Chemical · 2018Article
- Ultracompact Microwatt CMOS Current Readout With Picoampere Noise and Kilohertz Bandwidth for Biosensor Arrays.IEEE transactions on biomedical circuits and systems · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
The electrical properties of biological cells have connections to their pathological states. Here we present an electric impedance microflow cytometry (EIMC) platform for the characterization of disease states of single cells. This platform entails a microfluidic device for a label-free and non-invasive cell-counting assay through electric impedance sensing. We identified a dimensionless offset parameter δ obtained as a linear combination of a normalized phase shift and a normalized magnitude shift in electric impedance to differentiate cells on the basis of their pathological states. This paper discusses a representative case study on red blood cells (RBCs) invaded by the malaria parasite Plasmodium falciparum. Invasion by P. falciparum induces physical and biochemical changes on the host cells throughout a 48-h multi-stage life cycle within the RBC. As a consequence, it also induces progressive changes in electrical properties of the host cells. We demonstrate that the EIMC system in combination with data analysis involving the new offset parameter allows differentiation of P. falciparum infected RBCs from uninfected RBCs as well as among different P. falciparum intraerythrocytic asexual stages including the ring stage. The representative results provided here also point to the potential of the proposed experimental and analysis platform as a valuable tool for non-invasive diagnostics of a wide variety of disease states and for cell separation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.