ArticleMolecules (Basel, Switzerland)2013
Synthesis of new acadesine (AICA-riboside) analogues having acyclic D-ribityl or 4-hydroxybutyl chains in place of the ribose.
Article in Molecules (Basel, Switzerland), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- New Linear Precursors of cIDPR Derivatives as Stable Analogs of cADPR: A Potent Second Messenger with CaMarine drugs · 2019Article
- Synthesis and Biological Evaluation of a New Structural Simplified Analogue of cADPR, a Calcium-Mobilizing Secondary Messenger Firstly Isolated from Sea Urchin Eggs.Marine drugs · 2018Article
- 5-Amino-1-(2',3'-Acta crystallographica. Section E, Crystallographic communications · 2017Article
- Synthesis of cyclic N (1)-pentylinosine phosphate, a new structurally reduced cADPR analogue with calcium-mobilizing activity on PC12 cells.Beilstein journal of organic chemistry · 2015Article
- Synthesis and pharmacological evaluation of modified adenosines joined to mono-functional platinum moieties.Molecules (Basel, Switzerland) · 2014Article
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Authors and funding
8 authors.
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Abstract
The antiviral activity of certain acyclic nucleosides drew our attention to the fact that the replacement of the furanose ring by an alkyl group bearing hydroxyl(s) could be a useful structural modification to modulate the biological properties of those nucleosides. Herein, we report on the synthesis of some novel acadesine analogues, where the ribose moiety is mimicked by a D-ribityl or by a hydroxybutyl chain.
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