ReviewInternational journal of environmental research and public health2013
The dynamics of autism spectrum disorders: how neurotoxic compounds and neurotransmitters interact.
Review in International journal of environmental research and public health, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed.
- β-hydroxybutyrate restores social deficits by suppressing HDAC9 in the ACC of Shank3B-deficient mice.EMBO molecular medicine · 2026Article
- Natural products modulate social behavior and gut microbiota in a valproic acid-induced zebrafish model of autism spectrum disorder.Biomolecules & biomedicine · 2026Article
- Integrating Gut-Brain Axis: Exploring the Neurogastrointestinal Interactions and Therapeutic Potentials in Autism Spectrum Disorder.Endocrine, metabolic & immune disorders drug targets · 2026Review
- Transgenerational toxicity of Aroclor 1232 by inhalational route in mouse model.Toxicology reports · 2025Article
- Gamma-aminobutyric acid and glutamate system dysregulation in a small population of Egyptian children with autism spectrum disorder.Metabolic brain disease · 2025Article
- Autism spectrum disorder and the role of nuclear hormone receptors: insights and therapeutic implications.Frontiers in neuroscience · 2025Review
- Dysregulation of G protein subunits in autism: decreased GNAO1 and elevated GNAI1 levels in ASD.Frontiers in psychiatry · 2025Article
- Therapeutic effects ofFrontiers in pharmacology · 2025Article
- Metabolomic changes in children with autism.World journal of clinical pediatrics · 2024Article
- Recent advances and current challenges of new approach methodologies in developmental and adult neurotoxicity testing.Archives of toxicology · 2024Review
- Identification of Neurotransmission and Synaptic Biological Processes Disrupted in Autism Spectrum Disorder Using Interaction Networks and Community Detection Analysis.Biomedicines · 2023Article
- Prenatal SSRI Exposure Increases the Risk of Autism in Rodents via Aggravated Oxidative Stress and Neurochemical Changes in the Brain.Metabolites · 2023Article
- Probiotic Ameliorating Effects of Altered GABA/Glutamate Signaling in a Rodent Model of Autism.Metabolites · 2022Article
- GABA Receptor SNPs and Elevated Plasma GABA Levels Affect the Severity of the Indian ASD Probands.Journal of molecular neuroscience : MN · 2022Article
- Astrocytes derived from ASD individuals alter behavior and destabilize neuronal activity through aberrant CaMolecular psychiatry · 2022Article
- Article
- Knowledge and Attitudes toward Autism Spectrum Disorder in Saudi Arabia.International journal of environmental research and public health · 2022Article
- The Absence of Caspase-8 in the Dopaminergic System Leads to Mild Autism-like Behavior.Frontiers in cell and developmental biology · 2022Article
- The Effect of Lead Exposure on Autism Development.International journal of molecular sciences · 2021Review
- Dysregulation of Neuronal Nicotinic Acetylcholine Receptor-Cholesterol Crosstalk in Autism Spectrum Disorder.Frontiers in molecular neuroscience · 2021Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In recent years concern has risen about the increasing prevalence of Autism Spectrum Disorders (ASD). Accumulating evidence shows that exposure to neurotoxic compounds is related to ASD. Neurotransmitters might play a key role, as research has indicated a connection between neurotoxic compounds, neurotransmitters and ASD. In the current review a literature overview with respect to neurotoxic exposure and the effects on neurotransmitter systems is presented. The aim was to identify mechanisms and related factors which together might result in ASD. The literature reported in the current review supports the hypothesis that exposure to neurotoxic compounds can lead to alterations in the GABAergic, glutamatergic, serotonergic and dopaminergic system which have been related to ASD in previous work. However, in several studies findings were reported that are not supportive of this hypothesis. Other factors also might be related, possibly altering the mechanisms at work, such as time and length of exposure as well as dose of the compound. Future research should focus on identifying the pathway through which these factors interact with exposure to neurotoxic compounds making use of human studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.