ArticleScientific reports2013
The Directive 2010/63/EU on animal experimentation may skew the conclusions of pharmacological and behavioural studies.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Creation of Chemically Tri-Layered Collagen Crosslinked Membranes and Their Comparison with Ionically Tri-Layered Chitosan Crosslinked Membranes to Study Human Skin Properties.International journal of molecular sciences · 2023Article
- Anti-Anemic Effect of Antioxidant-Rich Apple Vinegar against Phenylhydrazine-Induced Hemolytic Anemia in Rats.Life (Basel, Switzerland) · 2022Article
- Using Mice to Model Human Disease: Understanding the Roles of Baseline Housing-Induced and Experimentally Imposed Stresses in Animal Welfare and Experimental Reproducibility.Animals : an open access journal from MDPI · 2022Review
- Exposure to 3'Sialyllactose-Poor Milk during Lactation Impairs Cognitive Capabilities in Adulthood.Nutrients · 2021Article
- The use of large animals to facilitate the process of MSC going from laboratory to patient-'bench to bedside'.Cell biology and toxicology · 2020Review
- Housing mice in the individually ventilated or open cages-Does it matter for behavioral phenotype?Genes, brain, and behavior · 2019Article
- Laboratory mouse housing conditions can be improved using common environmental enrichment without compromising data.PLoS biology · 2018Article
- The Impact of Housing Temperature-Induced Chronic Stress on Preclinical Mouse Tumor Models and Therapeutic Responses: An Important Role for the Nervous System.Advances in experimental medicine and biology · 2017Article
- Effect of Enrichment Devices on Aggression in Manipulated Nude Mice.Journal of the American Association for Laboratory Animal Science : JAALAS · 2015Article
- Mice repeatedly exposed to Group-A β-Haemolytic Streptococcus show perseverative behaviors, impaired sensorimotor gating, and immune activation in rostral diencephalon.Scientific reports · 2015Article
- Human-animal chimera: a neuro driven discussion? Comparison of three leading European research countries.Science and engineering ethics · 2015Article
- The Snark was a Boojum - reloaded.Frontiers in zoology · 2015Review
- Prenatal corticosterone and adolescent URB597 administration modulate emotionality and CB1 receptor expression in mice.Psychopharmacology · 2014Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
All laboratory animals shall be provided some form of environmental enrichment (EE) in the nearest future (Directive 2010/63/EU). Displacing standard housing with EE entails the possibility that data obtained under traditional housing may be reconsidered. Specifically, while EE often contrasts the abnormalities of consolidated disease models, it also indirectly demonstrates that their validity depends on housing conditions. We mimicked a situation in which the consequences of a novel pharmacological compound were addressed before and after the adoption of the Directive. We sub-chronically exposed standard- or EE-reared adolescent CD1 mice (postnatal days 23-33) to the synthetic compound JWH-018, and evaluated its short- and long-term potential cannabinoid properties on: weight gain, locomotion, analgesia, motor coordination, body temperature, brain metabolism ((1)H MRI/MRS), anxiety- and depressive-related behaviours. While several parameters are modulated by JWH-018 independently of housing, other effects are environmentally mediated. The transition from standard housing to EE shall be carefully monitored.
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