ArticleThe ISME journal2014
Repeated triggering of sporulation in Bacillus subtilis selects against a protein that affects the timing of cell division.
Article in The ISME journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Stochastic phenotypic switching arises in response to directional selection in experimentally evolved multicellular yeast.Communications biology · 2025Article
- Attempts to limit sporulation in the probiotic strainAccess microbiology · 2023Article
- Article
- Diversity of bet-hedging strategies in microbial communities-Recent cases and insights.WIREs mechanisms of disease · 2022Review
- A spore quality-quantity tradeoff favors diverse sporulation strategies in Bacillus subtilis.The ISME journal · 2020Article
- Ribosome Provisioning Activates a Bistable Switch Coupled to Fast Exit from Stationary Phase.Molecular biology and evolution · 2019Article
- Metabolic Perturbations in a Bacillus subtilis clpP Mutant during Glucose Starvation.Metabolites · 2017Article
- A Combination of Extreme Environmental Conditions Favor the Prevalence of Endospore-Forming Firmicutes.Frontiers in microbiology · 2016Article
- Phenotypic Heterogeneity, a Phenomenon That May Explain Why Quorum Sensing Does Not Always Result in Truly Homogenous Cell Behavior.Applied and environmental microbiology · 2015Review
- Bistability in a metabolic network underpins the de novo evolution of colony switching in Pseudomonas fluorescens.PLoS biology · 2015Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacillus subtilis sporulation is a last-resort phenotypical adaptation in response to starvation. The regulatory network underlying this developmental pathway has been studied extensively. However, how sporulation initiation is concerted in relation to the environmental nutrient availability is poorly understood. In a fed-batch fermentation set-up, in which sporulation of ultraviolet (UV)-mutagenized B. subtilis is repeatedly triggered by periods of starvation, fitter strains with mutated tagE evolved. These mutants display altered timing of phenotypical differentiation. The substrate for the wall teichoic acid (WTA)-modifying enzyme TagE, UDP-glucose, has recently been shown to be an intracellular proxy for nutrient availability, and influences the timing of cell division. Here we suggest that UDP-glucose also influences timing of cellular differentiation.
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Registered trials
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