ArticleThe journal of physical chemistry. B2013
Physiochemical properties of Caulobacter crescentus holdfast: a localized bacterial adhesive.
Article in The journal of physical chemistry. B, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 55 citations in OpenAlex.
- The coccosphere of the heavy calcifying coccolithophore Coccolithus braarudii provides defense against bacteria.Communications biology · 2026Article
- Sticking to Green: Sustainable Solutions for Next-Generation Microelectronic Packaging with Plant-Derived and Bacterial Adhesives.ACS sustainable chemistry & engineering · 2025Review
- Bacteria in Fluid Flow.Journal of bacteriology · 2023Review
- eDNA-stimulated cell dispersion fromeLife · 2023Article
- Bio-inspired adhesive hydrogel for biomedicine-principles and design strategies.Smart medicine · 2022Review
- HfaE Is a Component of the Holdfast Anchor Complex That Tethers the Holdfast Adhesin to the Cell Envelope.Journal of bacteriology · 2022Article
- What Glues the Glue to the Cell Surface?Journal of bacteriology · 2022Article
- Evaluation of Potential Probiotic Properties of a Strain ofFrontiers in microbiology · 2022Article
- A polysaccharide deacetylase enhances bacterial adhesion in high-ionic-strength environments.iScience · 2021Article
- Making the Enterobacterial Common Antigen Glycan and Measuring Its Substrate Sequestration.ACS chemical biology · 2021Article
- Biofilm-inspired adhesive and antibacterial hydrogel with tough tissue integration performance for sealing hemostasis and wound healing.Bioactive materials · 2020Article
- Comparative Analysis of Ionic Strength Tolerance between Freshwater and MarineJournal of bacteriology · 2019Article
- Composition of the Holdfast Polysaccharide fromJournal of bacteriology · 2019Article
- Article
- Regulation of bacterial surface attachment by a network of sensory transduction proteins.PLoS genetics · 2019Article
- A Genome-Wide Analysis of Adhesion inmBio · 2019Article
- Reciprocal control of motility and biofilm formation by the PdhS2 two-component sensor kinase of Agrobacterium tumefaciens.Microbiology (Reading, England) · 2019Article
- Bacterial adhesion at the single-cell level.Nature reviews. Microbiology · 2018Review
- Feedback regulation of Caulobacter crescentus holdfast synthesis by flagellum assembly via the holdfast inhibitor HfiA.Molecular microbiology · 2018Article
- Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
To colonize surfaces, the bacterium Caulobacter crescentus employs a polar polysaccharide, the holdfast, located at the end of a thin, long stalk protruding from the cell body. Unlike many other bacteria which adhere through an extended extracellular polymeric network, the holdfast footprint area is tens of thousands times smaller than that of the total bacterium cross-sectional surface, making for some very demanding adhesion requirements. At present, the mechanism of holdfast adhesion remains poorly understood. We explore it here along three lines of investigation: (a) the impact of environmental conditions on holdfast binding affinity, (b) adhesion kinetics by dynamic force spectroscopy, and (c) kinetic modeling of the attachment process to interpret the observed time-dependence of the adhesion force at short and long time scales. A picture emerged in which discrete molecular units called adhesins are responsible for initial holdfast adhesion, by acting in a cooperative manner.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.