ArticleLipids in health and disease2013
High conjugated linoleic acid enriched ghee (clarified butter) increases the antioxidant and antiatherogenic potency in female Wistar rats.
Article in Lipids in health and disease, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 81 citations in OpenAlex.
- The Effect of Conjugated Linoleic Acid Supplementation on Densitometric Parameters in Overweight and Obese Women-A Randomised Controlled Trial.Medicina (Kaunas, Lithuania) · 2023Trial
- Conjugated linoleic acid improves glycemic response, lipid profile, and oxidative stress in obese patients with non-alcoholic fatty liver disease: a randomized controlled clinical trial.Croatian medical journal · 2016Trial
- Effects of Supplementing the Diets of Mice With Different Concentrations of Conjugated Linoleic Acid on the Anti-Inflammatory Function of the Mammary Gland.Food science & nutrition · 2026Article
- Polyphenol-Rich Mangosteen Pericarp Extract Attenuates Metabolic and Reproductive Dysfunction in High-fat Diet and Streptozotocin-induced Obese-Diabetic Male Rats: A Preliminary Study.Applied biochemistry and biotechnology · 2026Article
- Protective effects of linoleic acid against E. coli lipopolysaccharide-induced oxidative and nitrosative toxicity in buffalo luteal cell culture.BMC veterinary research · 2026Article
- Therapeutic potential of popular fermented dairy products and its benefits on human health.Frontiers in nutrition · 2024Review
- Beneficial Effects of Polyphenol-Rich Food Oils in Cardiovascular Health and Disease.Reviews in cardiovascular medicine · 2023Review
- Article
- Improving obesity and lipid metabolism using conjugated linoleic acid.Veterinary medicine and science · 2022Article
- Lipid profile in healthy human volunteers before and after consuming ghee.Bioinformation · 2022Article
- Milk Fatty Acid Profiles in Different Animal Species: Focus on the Potential Effect of Selected PUFAs on Metabolism and Brain Functions.Nutrients · 2021Review
- Fluorescence Spectroscopy Based Detection of Adulteration in Desi Ghee.Journal of fluorescence · 2020Article
- Studying heating effects on desi ghee obtained from buffalo milk using fluorescence spectroscopy.PloS one · 2018Article
- Comparison between the Effect of Cow Ghee and Butter on Memory and Lipid Profile of Wistar Rats.Journal of clinical and diagnostic research : JCDR · 2016Article
- Characterization of CLA-producing Butyrivibrio spp. reveals strain-specific variations.3 Biotech · 2016Article
- Impact on human health of microorganisms present in fermented dairy products: an overview.BioMed research international · 2015Review
- Modulation of Metabolic Detoxification Pathways Using Foods and Food-Derived Components: A Scientific Review with Clinical Application.Journal of nutrition and metabolism · 2015Review
- Butter naturally enriched in cis-9, trans-11 CLA prevents hyperinsulinemia and increases both serum HDL cholesterol and triacylglycerol levels in rats.Lipids in health and disease · 2014Article
- Panchgavya and cow products: A trail for the holy grail.Journal of Ayurveda and integrative medicineArticle
- Short term escalating administration of large amount of sneha does not increase blood lipids.Journal of Ayurveda and integrative medicineArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHypercholesterolemia and oxidative stress are the main stimulating factors responsible for coronary artery disease and progression of atherosclerosis. Dairy food products are rich in conjugated linoleic acid (CLA) which is considered as an important component due to its potential health benefits such as anticarcinogenic, antiatherogenic, antidiabetic and antiadipogenic properties. In the present study, the effect of CLA enriched ghee on the antioxidant enzyme system and antiatherogenic properties in Wistar rats has been studied.
methodsFemale Wistar rats of 21 days were taken for the study and fed with soybean diet (Control diet), low CLA diet and high CLA ghee diet (treatments) for thirty five days for studying antioxidative enzymes and sixteen weeks in case of antiatherogenic studies.
resultsFeeding of high CLA enhanced ghee during pubescent period in rats lead to an increase in catalase (CAT) and superoxide dismutase (SOD) enzyme activities in blood and increased CAT, SOD and glutathione transferase (GST) enzymes activities in liver by 27, 130 and 168 percent, respectively. Plasma nitrate concentration and Haemoglobin levels remained the same in all the treatments. Feeding of high CLA ghee resulted in lower (P < 0.01) plasma cholesterol & triglyceride level (52.17 and 30.27%), and higher high density lipoproteins (33.26%) than feeding of soybean oil (control group) and thus manifested in decreased (P < 0.05) atherogenic index (from 0.472 to 0.244). Lesser cholesterol and triglyceride levels were observed in the liver and aorta of high CLA fed rats than in those of the other groups. Histopathological studies of liver showed normal hepatic cords with portal triad in the high CLA ghee fed rats whereas fatty degeneration of hepatocytes containing fat vacuoles was observed in the liver of the other groups.
conclusionThis paper is the first report of the antioxidant and antiatherogenic properties of the high CLA enriched ghee suggesting that high CLA ghee can be used as a potential food for decreasing the risk of cardiovascular diseases, particularly in India, where, ghee is widely used for culinary and medicinal purposes.
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